1, 2, 4-triazole: a privileged scaffold for the development of potent antifungal agents-a brief review

C Tratrat - Current Topics in Medicinal Chemistry, 2020 - ingentaconnect.com
Over the past decades, a tremendous rise in invasive fungal infection diseases attributed to
the yeast Candida albicans in immunocompromised individuals poses a seriously …

Prospects for the search for new biologically active compounds among the derivatives of the heterocyclic system of 1, 2, 4-triazole

Y Sameliuk, A Kaplaushenko… - … University Journal of …, 2022 - dergipark.org.tr
The purpose of this literature review was to systematize data from studies of the biological
activity of 1, 2, 4-triazole derivatives with substituents in positions 4 and 5. The authors set …

Design, synthesis, characterization and antimicrobial evaluation of some novel hydrazinecarbothioamide, 4‐thiazolidinone and 1, 2, 4‐triazole‐3‐thione derivatives

ED Dincel, N Ulusoy‐Güzeldemirci… - Journal of …, 2021 - Wiley Online Library
A series of novel hydrazinecarbothioamide (5a, c, f), 4‐thiazolidinone (6a‐e), and 1, 2, 4‐
triazole‐3‐thione (7a‐d) were designed and synthesized. The structural elucidations of the …

Synthesis, antimicrobial and antifungal activity of ylidenhydrazides of 2-((4-R-5-R1-4H-1, 2, 4-triazol-3-yl) thio) acetaldehydes

R Shcherbyna, O Panasenko, O Polonets… - Journal of Faculty of …, 2021 - dergipark.org.tr
Objective: The aim of this work is the synthesis and studying of antimicrobial and antifungal
properties of the ylidenhydrazides of 2-((4-R-5-R1-4H-1, 2, 4-triazol-3-yl) thio) …

Design, synthesis and molecular docking of some derivatives of 9-methylpyrazolo [1, 5-d][1, 2, 4] triazolo [3, 4-f][1, 2, 4] triazine-3-thiol

S Fedotov, A Gotsulya, Y Zaika… - Journal of Faculty of …, 2023 - dergipark.org.tr
Objective: The purpose of the work was to elaboration effective techniques for the synthesis
of advanced condensed heterocyclic systems based on pyrazole and 1, 2, 4-triazole. In the …

[PDF][PDF] Synthesis and exploring novel annulated 1, 3-diphenylpyrazole derivatives as antimicrobial and anticancer agents

SS Mohamed, SN Shabaan, NF Abdelghaffar… - J. Basic Environ …, 2021 - researchgate.net
A novel series of annulated diphenylpyrazoles were designed and synthesized through
various strategies. The bifunctional enaminonitrile 1 used as the key intermediate to prepare …

1, 2, 4-Triazole derivatives in medicine and pharmacy and application prospects

Y Sameliuk, T Kaplaushenko… - Journal of Faculty of …, 2021 - dergipark.org.tr
Objective: Development of methods for the synthesis, studies of chemical, physico-chemical
and biological properties of 1, 2, 4-triazole derivatives, in particular compounds with …

N'-(2-(5-((Theophylline-7-yl) methyl)-4-ethyl-1, 2, 4-triazole-3-ylthio) acetyl) isonicotinohydrazide As Antitubercular Agents

A Gotsulya, V Zazharskyı, V Parchenko… - … University Journal of …, 2022 - dergipark.org.tr
The paper presents the results of histological studies of tuberculosis in rabbits in an
experimental model with comparative treatment with isoniazid and N'-(2-(5-((theophylline-7 …

Synthesis and properties of S-alkyl 4-amino-5-(5-(3-fluorophenyl)-pyrazol-3-yl)-1, 2, 4-triazole-3-thiol derivatives

SO Fedotov, AS Hotsulia - 2023 - dspace.zsmu.edu.ua
Materials and methods. The synthesis of the target products of chemical transformation was
successfully implemented by the step-by-step use of well-known methods of organic …

Synthesis and properties of 3-(ethylthio)-9-methyl-6-(alkylthio) pyrazolo [1, 5-d][1, 2, 4] triazolo [3, 4-f][1, 2, 4] triazines

SO Fedotov, AS Hotsulia - 2022 - dspace.zsmu.edu.ua
Materials and methods. The chemical part of the work involved the step-by-step creation of
target reaction products in the form of 3-(ethylthio)-9-methyl-6-(alkylthio) pyrazolo [1, 5-d][1 …