The Hedgehog signalling pathway has crucial roles in embryonic tissue patterning,
postembryonic tissue regeneration, and cancer, yet aspects of Hedgehog signal …

Despite decades of research, brain tumours remain among the deadliest of all forms of
cancer. The ability of these tumours to resist almost all conventional and novel treatments …

Primary cilia project in a single copy from the surface of most vertebrate cell types; they
detect and transmit extracellular cues to regulate diverse cellular processes during …

Medulloblastoma, a malignant childhood cerebellar tumour, segregates molecularly into
biologically distinct subgroups, suggesting that a personalized approach to therapy would …

Primary cilia are solitary, immotile sensory organelles present on most cells in the body that
participate broadly in human health, physiology and disease. Cilia generate a unique …

Idiopathic pulmonary fibrosis (IPF) is a progressive and terminal lung disease with no known
cure. IPF is a disease of aging, with median age of diagnosis over 65 years. Median survival …

Medulloblastoma (MB) comprises a biologically heterogeneous group of embryonal tumours
of the cerebellum. Four subgroups of MB have been described (WNT, sonic hedgehog …

The sonic hedgehog (Shh) signaling pathway is a major regulator of cell differentiation, cell
proliferation, and tissue polarity. Aberrant activation of the Shh pathway has been shown in …

Medulloblastoma is a highly malignant paediatric brain tumour currently treated with a
combination of surgery, radiation and chemotherapy, posing a considerable burden of …

Medulloblastoma is the most common malignant brain tumor in childhood. Molecular studies
from several groups around the world demonstrated that medulloblastoma is not one …