Variant surface antigens of Plasmodium falciparum and their roles in severe malaria
Proliferation and differentiation inside erythrocytes are important steps in the life cycle of
Plasmodium spp. To achieve these, the parasites export polypeptides to the surface of …
Plasmodium spp. To achieve these, the parasites export polypeptides to the surface of …
[HTML][HTML] Sticking for a cause: the falciparum malaria parasites cytoadherence paradigm
After a successful invasion, malaria parasite Plasmodium falciparum extensively remodels
the infected erythrocyte cellular architecture, conferring cytoadhesive properties to the …
the infected erythrocyte cellular architecture, conferring cytoadhesive properties to the …
[HTML][HTML] Host-parasite interactions during Plasmodium infection: Implications for immunotherapies
Malaria is a global infectious disease that remains a leading cause of morbidity and mortality
in the developing world. Multiple environmental and host and parasite factors govern the …
in the developing world. Multiple environmental and host and parasite factors govern the …
An exported protein-interacting complex involved in the trafficking of virulence determinants in Plasmodium-infected erythrocytes
The malaria parasite, Plasmodium falciparum, displays the P. falciparum erythrocyte
membrane protein 1 (Pf EMP1) on the surface of infected red blood cells (RBCs). We here …
membrane protein 1 (Pf EMP1) on the surface of infected red blood cells (RBCs). We here …
[PDF][PDF] Protective immunity against severe malaria in children is associated with a limited repertoire of antibodies to conserved PfEMP1 variants
SK Tessema, R Nakajima, A Jasinskas, SL Monk… - Cell host & …, 2019 - cell.com
Extreme diversity of the major Plasmodium falciparum antigen, PfEMP1, poses a barrier to
identifying targets of immunity to malaria. Here, we used protein microarrays containing …
identifying targets of immunity to malaria. Here, we used protein microarrays containing …
Three is a crowd–new insights into rosetting in Plasmodium falciparum
XY Yam, M Niang, KG Madnani, PR Preiser - Trends in Parasitology, 2017 - cell.com
The intracellular malaria parasites extensively modify host erythrocytes to allow nutrient
uptake, ensure homeostasis, and evade the host's immune response. To achieve this, the …
uptake, ensure homeostasis, and evade the host's immune response. To achieve this, the …
[HTML][HTML] Distinct amino acid and lipid perturbations characterize acute versus chronic malaria
RJ Cordy, R Patrapuvich, LN Lili, M Cabrera-Mora… - JCI insight, 2019 - ncbi.nlm.nih.gov
Chronic malaria is a major public health problem and significant challenge for disease
eradication efforts. Despite its importance, the biological factors underpinning chronic …
eradication efforts. Despite its importance, the biological factors underpinning chronic …
The knob protein KAHRP assembles into a ring-shaped structure that underpins virulence complex assembly
O Looker, AJ Blanch, B Liu, J Nunez-Iglesias… - PLoS …, 2019 - journals.plos.org
Plasmodium falciparum mediates adhesion of infected red blood cells (RBCs) to blood
vessel walls by assembling a multi-protein complex at the RBC surface. This virulence …
vessel walls by assembling a multi-protein complex at the RBC surface. This virulence …
Evolutionary analyses of the major variant surface antigen-encoding genes reveal population structure of Plasmodium falciparum within and between continents
Malaria remains a major public health problem in many countries. Unlike influenza and HIV,
where diversity in immunodominant surface antigens is understood geographically to inform …
where diversity in immunodominant surface antigens is understood geographically to inform …