This new diagnostic consensus guideline is a joint project of the European Crohn's and
Colitis Organisation [ECCO] and the European Society of Gastrointestinal and Abdominal …

Intestinal fibrosis, which is usually the consequence of chronic inflammation, is a common
complication of inflammatory bowel disease (IBD), including Crohn's disease and ulcerative …

Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the gastrointestinal
tract. Cytokine-targeted therapies have transformed the treatment of IBD, providing control of …

The gastrointestinal tract has the important task of absorbing nutrients, a complex process
that requires an intact barrier allowing the passage of nutrients but that simultaneously …

Many chronic diseases are marked by fibrosis, which is defined by an abundance of
activated fibroblasts and excessive deposition of extracellular matrix, resulting in loss of …

Genetic alterations affecting transforming growth factor–β (TGF-β) signaling are
exceptionally common in diseases and cancers of the gastrointestinal system. As a regulator …

Macrophages, which are functional plasticity cells, have the ability to phagocytize and digest
foreign substances and acquire pro-(M1-like) or anti-inflammatory (M2-like) phenotypes …

Abstract Inflammatory Bowel Diseases (IBD), namely Crohn's Disease and Ulcerative Colitis,
cause a significant disease burden in modern civilization. Ever since the introduction of anti …

Background Inflammatory bowel disease (IBD) is a chronic nonspecific disease with
unknown etiology. Currently, the anti-inflammatory therapeutic approaches have achieved a …

Fibrosis refers to the excessive deposition of extracellular matrix components in the
processes of wound repair or tissue regeneration after tissue damage. Fibrosis occurs in …