Abstract The Tubulin Code revolutionizes our understanding of microtubule dynamics and
functions, proposing a nuanced system governed by tubulin isotypes, posttranslational …

Microglia dynamically reorganize their cytoskeleton to perform essential functions such as
phagocytosis of toxic protein aggregates, surveillance of the brain parenchyma, and …

Ciliopathies are often caused by defects in the ciliary microtubule core. Glutamylation is
abundant in cilia, and its dysregulation may contribute to ciliopathies and …

Microtubule-associated protein 1a (Map1a) is a microtubule (MT) regulatory protein that
binds to the MT protofilaments in mammalian cells to promote MT stabilization. Maps work …

Abstract Mutations in Cytosolic Carboxypeptidase-like Protein 5 (CCP5) are associated with
vision loss in humans. To decipher the mechanisms behind CCP5-associated blindness, we …

Microtubules are dynamic polymers assembled from αβ-tubulin dimers. Mammals have
multiple α and β-tubulin isoforms. Despite a high degree of conservation, microtubules …

The transition zone (TZ) regulates cilia composition and function. Canonical TZs with 9
doublet microtubules (MTs) are common but non-canonical TZs that vary from 9 MT …

The cytoskeleton of eukaryotic cells consists of microtubules, actin and intermediate
filaments, which are highly interconnected and compartmentalized in polarized cells, such …

The present work aims at design and synthesis of a congeneric series of small hybrids 5 and
6a–i featuring the privileged quinoline scaffold tethered with 2-(arylamido) cinnamide moiety …

Ciliopathies are often caused by defects in the ciliary microtubule core. Glutamylation is
abundant in cilia, and its dysregulation may contribute to ciliopathies and …