Adiponectin, a therapeutic target for obesity, diabetes, and endothelial dysfunction

AE Achari, SK Jain - International journal of molecular sciences, 2017 - mdpi.com
Adiponectin is the most abundant peptide secreted by adipocytes, whose reduction plays a
central role in obesity-related diseases, including insulin resistance/type 2 diabetes and …

Cellular bioenergetics as a target for obesity therapy

YH Tseng, AM Cypess, CR Kahn - Nature reviews Drug discovery, 2010 - nature.com
Obesity develops when energy intake exceeds energy expenditure. Although most current
obesity therapies are focused on reducing calorific intake, recent data suggest that …

The impact of marijuana use on glucose, insulin, and insulin resistance among US adults

EA Penner, H Buettner, MA Mittleman - The American journal of medicine, 2013 - Elsevier
BACKGROUND: There are limited data regarding the relationship between cannabinoids
and metabolic processes. Epidemiologic studies have found lower prevalence rates of …

A high ratio of dietary n-3/n-6 polyunsaturated fatty acids improves obesity-linked inflammation and insulin resistance through suppressing activation of TLR4 in SD …

HQ Liu, Y Qiu, Y Mu, XJ Zhang, L Liu, XH Hou, L Zhang… - Nutrition research, 2013 - Elsevier
Dietary ratios of n-3/n-6 polyunsaturated fatty acids (PUFAs) have been implicated in
controlling markers of metabolic disorders, including obesity, insulin resistance (IR) …

Influence of obesity on the risk of esophageal disorders

J Lagergren - Nature reviews Gastroenterology & hepatology, 2011 - nature.com
Obesity is associated with an increased risk of esophageal disorders, including esophageal
adenocarcinoma, Barrett esophagus and GERD. For reasons yet unknown, the association …

[HTML][HTML] Hematological alterations in diabetic rats-role of adipocytokines and effect of citrus flavonoids

AM Mahmoud - Excli Journal, 2013 - ncbi.nlm.nih.gov
Dysfunction in adipocytes is associated with insulin resistance and type 2 diabetes.
Diabetes-associated anemia has been reported due to the increased non-enzymatic …

Injectable allograft adipose matrix supports adipogenic tissue remodeling in the nude mouse and human

LE Kokai, BK Schilling, E Chnari… - Plastic and …, 2019 - journals.lww.com
Background: Adipose tissue reaches cellular stasis after puberty, leaving adipocytes unable
to significantly expand or renew under normal physiologic conditions. This is problematic in …

[HTML][HTML] Modulation of hyperglycemia and dyslipidemia in experimental type 2 diabetes by gallic acid and p-coumaric acid: The role of adipocytokines and PPARγ

A Abdel-Moneim, SM Abd El-Twab, AI Yousef… - Biomedicine & …, 2018 - Elsevier
There are many indications that confirm the vital role of adipocytokines and PPARγ in
diabetics. Hence, the current investigation aimed to study the modulatory effects of gallic …

Mechanisms of obesity and related pathologies: androgen deficiency and endothelial dysfunction may be the link between obesity and erectile dysfunction

AM Traish, RJ Feeley, A Guay - The FEBS journal, 2009 - Wiley Online Library
Obesity is associated with a high prevalence of erectile dysfunction; however, the
pathophysiological link between obesity and erectile dysfunction remains poorly …

High-molecular-weight adiponectin and the risk of type 2 diabetes in the ARIC study

N Zhu, JS Pankow, CM Ballantyne… - The Journal of …, 2010 - academic.oup.com
Context: Adiponectin, synthesized by adipocytes, has been shown to be a predictor of type 2
diabetes. Adiponectin circulates in plasma as three oligomeric isoforms. High-molecular …