For most organisms, computational operon predictions are the only source of genome-wide
operon information. Operon prediction methods described in literature are based on (a …

During in vitro broth culture, bacterial gene expression is typically dominated by highly
expressed factors involved in protein biosynthesis, maturation, and folding, but it is unclear if …

Bacterial small RNAs (sRNAs) function in post-transcriptional regulatory responses to
environmental changes. However, the lack of eukaryotic RNA interference-like machinery in …

So you think you finally understand the regulation of your favorite gene? The transcriptional
regulators have been identified; the signaling cascades that regulate synthesis and activity …

Interest in finding small RNAs (sRNAs) in bacteria has significantly increased in recent years
due to their regulatory functions. Development of high-throughput methods and more …

Background Computational and microarray-based experimental approaches were used to
generate a comprehensive transcript index for the human genome. Oligonucleotide probes …

Background The identification of non-coding transcripts in human, mouse, and Escherichia
coli has revealed their widespread occurrence and functional importance in both eukaryotic …

Abstract Background In Escherichia coli, approximately 100 regulatory small RNAs (sRNAs)
have been identified experimentally and many more have been predicted by various …

Identification and characterization of functional elements in the noncoding regions of
genomes is an elusive and time-consuming activity whose output does not keep up with the …

The progress in genome sequencing has led to a rapid accumulation in GenBank
submissions of uncharacterized 'hypothetical'genes. These genes, which have not been …