Formations of myofibers, osteoclasts, syncytiotrophoblasts, and fertilized zygotes share a
common step, cell–cell fusion. Recent years have brought about considerable progress in …

Fertilization is a multistep process that culminates in the fusion of sperm and egg, thus
marking the beginning of a new organism in sexually reproducing species. Despite its …

Fusion of plasma membranes is essential for skeletal muscle development, regeneration,
exercise-induced adaptations, and results in a cell that contains hundreds to thousands of …

Ebola viruses (EBOVs) assemble into filamentous virions, whose shape and stability are
determined by the matrix viral protein 40 (VP40). Virus entry into host cells occurs via …

Muscle cell fusion is a multistep process where the final step of the reaction drives
progression beyond early hemifusion events to complete fusion. This step requires activity of …

Interferon-induced transmembrane protein 3 (IFITM3) inhibits the entry of numerous viruses
through undefined molecular mechanisms. IFITM3 localizes in the endosomal-lysosomal …

Viral infections, fertilization, neurotransmission, and many other fundamental biological
processes rely on membrane fusion. Straightforward calculations based on the celebrated …

Krüppel-like factor 4 (KLF4) is an evolutionarily conserved zinc finger-containing
transcription factor that regulates diverse cellular processes such as cell proliferation …

Fusion of biological membranes is fundamental in various physiological events. The fusion
process involves several intermediate stages with energy barriers that are tightly dependent …

Background Skeletal muscle development and regeneration depend on cellular fusion of
myogenic progenitors to generate multinucleated myofibers. These progenitors utilize two …