Sepsis-associated acute kidney injury (S-AKI) is a frequent complication of the critically ill
patient and is associated with unacceptable morbidity and mortality. Prevention of S-AKI is …

Sepsis affects practically all aspects of endothelial cell (EC) function and is thought to be the
key factor in the progression from sepsis to organ failure. Endothelial functions affected by …

Given that the leading clinical conditions associated with acute kidney injury (AKI), namely,
sepsis, major surgery, heart failure, and hypovolemia, are all associated with shock, it is …

Sepsis is considered a major public health problem. Despite mortality being associated
consistently with organ compromise, the mechanisms by which sepsis causes multiple …

Acute kidney injury causes significant morbidity and mortality in the community and clinic.
Various pathologies, including renal and cardiovascular disease, traumatic …

Development of organ dysfunction is the most important clinical event during sepsis, as it
directly relates to mortality and morbidity. Although the new definition of sepsis captures this …

In patients with acute kidney injury (AKI), optimization of systemic haemodynamics is central
to the clinical management. However, considerable debate exists regarding the efficacy …

Sepsis-associated acute kidney injury (S-AKI) is a common complication in hospitalized and
critically ill patients, which increases the risk of multiple comorbidities and is associated with …

The pathogenesis of sepsis-associated acute kidney injury is complex and likely involves
perfusion alterations, a dysregulated inflammatory response, and bioenergetic …

Acute kidney injury (AKI) remains a major clinical event with rising incidence, severity, and
cost; it now has a morbidity and mortality exceeding acute myocardial infarction. There is …