[HTML][HTML] Food-borne chemical carcinogens and the evidence for human cancer risk

T Kobets, BPC Smith, GM Williams - Foods, 2022 - mdpi.com
Commonly consumed foods and beverages can contain chemicals with reported
carcinogenic activity in rodent models. Moreover, exposures to some of these substances …

[HTML][HTML] Next-generation DNA damage sequencing

C Mingard, J Wu, M McKeague, SJ Sturla - Chemical Society Reviews, 2020 - pubs.rsc.org
Cellular DNA is constantly chemically altered by exogenous and endogenous agents. As all
processes of life depend on the transmission of the genetic information, multiple biological …

The key characteristics of carcinogens: relationship to the hallmarks of cancer, relevant biomarkers, and assays to measure them

MT Smith, KZ Guyton, N Kleinstreuer, A Borrel… - … Biomarkers & Prevention, 2020 - AACR
The key characteristics (KC) of human carcinogens provide a uniform approach to
evaluating mechanistic evidence in cancer hazard identification. Refinements to the …

Organophosphate pesticide-induced toxicity through DNA damage and DNA repair mechanisms

J Prathiksha, RK Narasimhamurthy, HS Dsouza… - Molecular Biology …, 2023 - Springer
Organophosphate pesticides (OPs) are widely used in agriculture, healthcare, and other
industries due to their ability to kill pests. However, OPs can also have genotoxic effects on …

Nose to brain delivery of naringin-loaded chitosan nanoparticles for potential use in oxaliplatin-induced chemobrain in rats: impact on oxidative stress, cGAS/STING …

DMF Hanna, J Youshia, SF Fahmy… - Expert Opinion on Drug …, 2023 - Taylor & Francis
Objectives Oxaliplatin induces chemobrain in cancer patients/survivors. Nutraceutical
naringin has antioxidant and anti-inflammatory properties with low oral bioavailability. Our …

Main mechanisms for carcinogenic heterocyclic amine reduction in cooked meat by natural materials

HJ Kang, SY Lee, JH Kang, JH Kim, HW Kim, DH Oh… - Meat Science, 2022 - Elsevier
Carcinogens such as heterocyclic amine (HCA), produced during meat cooking, pose a risk
of digestive and reproductive cancers in humans. Nevertheless, the exact mechanisms for …

Mass spectrometry analysis of DNA and protein adducts as biomarkers in human exposure to cigarette smoking: acrolein as an example

HJC Chen - Chemical Research in Toxicology, 2023 - ACS Publications
Acrolein is a major component in cigarette smoke and a product of endogenous lipid
peroxidation. It is difficult to distinguish human exposure to acrolein from exogenous sources …

Precarcinogens in food–Mechanism of action, formation of DNA adducts and preventive measures

B Bukowska, P Duchnowicz, TB Tumer, J Michałowicz… - Food Control, 2023 - Elsevier
Food quality and food composition play key roles in human health. Food may contain
harmful ingredients apart from the basic ingredients beneficial to our body. A harmful group …

[HTML][HTML] The relationship between tobacco and breast cancer incidence: A systematic review and meta-analysis of observational studies

Y He, Y Si, X Li, J Hong, C Yu, N He - Frontiers in Oncology, 2022 - frontiersin.org
Background The effect of tobacco on breast cancer (BC) is controversial. The purpose of this
study was to investigate the relationship between tobacco and BC. Methods A search was …

[HTML][HTML] Mechanisms of E-Cigarette Vape-Induced Epithelial Cell Damage

E Auschwitz, J Almeda, CD Andl - Cells, 2023 - mdpi.com
E-cigarette use has been reported to affect cell viability, induce DNA damage, and modulate
an inflammatory response resulting in negative health consequences. Most studies focus on …