Psychosis is a common and distressing symptom in people with Alzheimer disease, and few
safe and effective treatments are available. However, new approaches to symptom …

Serotonin 5-HT2A receptors (5-HT2ARs) are widely distributed in the central nervous
system, especially in brain region essential for learning and cognition. In addition to …

Purpose A limit on developing new treatments for a number of central nervous system (CNS)
disorders has been the inadequate understanding of the in vivo pathophysiology underlying …

Alzheimer's disease (AD) is one of the major neurodegenerative diseases that deteriorates
cognitive functions and primarily affects associated brain regions involved in learning and …

Psychedelics are increasingly being recognized for their potential to treat a wide range of
brain disorders including depression, post‐traumatic stress disorder (PTSD), and substance …

The serotonergic system plays a key modulatory role in the brain and is the target for many
drug treatments for brain disorders either through reuptake blockade or via interactions at …

Serotonin (5-HT) is a neuromodulator–transmitter influencing global brain function. Past and
present findings illustrate a prominent role for 5-HT in the modulation of ponto-medullary …

Developing new therapies for Alzheimer's disease (AD) is critically important to avoid the
impending public health disaster imposed by this common disorder. Means must be found to …

The serotonergic system is one of the most important modulatory neurotransmitter systems
in the human brain. It plays a central role in major physiological processes and is implicated …

Neuron and synapse loss together with neurotransmitter dysfunction have, along with Aβ
deposition and neurofibrillary tangles, been recognized as hallmarks of Alzheimer's disease …