Autoimmune diseases present with varied and broad-ranging cutaneous manifestations.
Connective tissue disorders have a plethora of skin manifestations such as rheumatoid …

Abstract Localization of CD4+ CD25+ Foxp3+ regulatory T (Treg) cells to lymphoid and non-
lymphoid tissue is instrumental for the effective control of immune responses. Compared …

Type 1 diabetes is one of the most well‐characterized autoimmune diseases. Type 1
diabetes compromises an individual's insulin production through the autoimmune …

Transplantation is a successful treatment for end-stage organ failure. Despite improvements
in short-term outcome, long-term survival remains suboptimal because of the morbidity and …

Induction of a chronic eczema is a most efficient therapy for alopecia areata (AA). We had
noted a reduction in regulatory T cells during AA induction and wondered whether …

Immune responses against pathogens require fine regulation to avoid excessive
inflammation, which could be harmful to the host. Moreover, the immune system must be …

Autoimmune response suppression by regulatory T cells (Tregs) helps to maintain
peripheral immune tolerance, and defects in this mechanism are thought to play a role in the …

Early studies identified the CC-chemokine receptor (CCR) 7 as an important homing
molecule controlling the lymph node entry of naive T cells through high endothelial venules …

Generating and using regulatory T cells (Tregs) to modulate inflammatory disease
represents a valuable approach to therapy but has not yet been applied as a means to …

C57BL/6 mice infected with mouse hepatitis virus, strain JHM (JHMV) develop a rapidly fatal
acute encephalitis. Previously, we showed that this disease is partially CD4 T cell-mediated …