The healthy host does not normally develop tissue destructive autoimmunity in part because
of the presence of natural regulatory T cells. These cells are best identified by their …

Abstract Midkine (MK), a heparin-binding growth factor, reportedly contributes to
inflammatory diseases, including Crohn's disease and rheumatoid arthritis. We previously …

BACKGROUND: Regulatory T (Treg) cells induced by UV radiation (UVR) inhibit only the
induction and not the elicitation of contact hypersensitivity (CHS) because they migrate into …

In recent years, there has been a revival of the concept of CD4+ regulatory T (Treg) cells as
being a central control point in various immune responses, including autoimmune …

Abstract CD4+ CD25+ FoxP3+ regulatory T cells (Treg) have been shown to be protective in
animal models of autoimmunity and acute graft-vs-host disease. However, owing to the …

We will take a journey from basic pathogenetic mechanisms elicited by viral infections that
play a role in the development of type 1 diabetes to clinical interventions, where we will …

Originally interpreted within the framework of a binary TH1/TH2 paradigm, our knowledge of
the pathogenesis of atopic diseases has broadened to incorporate the contribution of T …

Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease that develops in
about 5 per 1000 people. Over the past years, substantial progresses in knowledge of the …

FTY720 has been used to control inflammatory lesions, but the mechanisms by which the
drug acts in vivo are poorly understood. Such mechanisms may result primarily from effects …

Recent studies indicate that genes located on the X-chromosome play a major and unique
role in autoimmunity. The fact that most X-linked primary immune deficiencies carry …