The pre-clinical phase of rheumatoid arthritis: from risk factors to prevention of arthritis

N Petrovská, K Prajzlerová, J Vencovský, L Šenolt… - Autoimmunity …, 2021 - Elsevier
Rheumatoid arthritis (RA) is a chronic autoimmune disease considered as a multistep
process spanning from the interaction of genetic (eg, shared epitope or non-HLA loci) …

[HTML][HTML] Transformation of fibroblast‐like synoviocytes in rheumatoid arthritis; from a friend to foe

MJ Mousavi, J Karami, S Aslani, MN Tahmasebi… - Autoimmunity …, 2021 - Springer
Swelling and the progressive destruction of articular cartilage are major characteristics of
rheumatoid arthritis (RA), a systemic autoimmune disease that directly affects the synovial …

[HTML][HTML] Academic Textbook: The Role of Melatonin in Pathogenesis and Treatment of Autoimmune Diseases

SOH Tabatabaei, R Moazamiyanfar, AM Fard… - Kindle, 2022 - preferpub.org
An association of melatonin levels with age disease initiation of autoimmune diseases and
pineal calcification was reported while an inverse association between melatonin levels and …

Synovial fibroblasts as potential drug targets in rheumatoid arthritis, where do we stand and where shall we go?

T Németh, G Nagy, T Pap - Annals of the Rheumatic Diseases, 2022 - ard.bmj.com
Fibroblast-like synoviocytes or synovial fibroblasts (FLS) are important cellular components
of the inner layer of the joint capsule, referred to as the synovial membrane. They can be …

Destructive roles of fibroblast-like synoviocytes in chronic inflammation and joint damage in rheumatoid arthritis

M Masoumi, H Bashiri, H Khorramdelazad… - Inflammation, 2021 - Springer
Fibroblast-like synoviocytes (FLSs) are important non-immune cells located mostly in the
inner layer of the synovium. Indeed, these cells are specialized mesenchymal cells …

[HTML][HTML] Epigenomic and transcriptomic analyses reveal differences between low-grade inflammation and severe exhaustion in LPS-challenged murine monocytes

LB Naler, YP Hsieh, S Geng, Z Zhou, L Li… - Communications …, 2022 - nature.com
Emerging studies suggest that monocytes can be trained by bacterial endotoxin to adopt
distinct memory states ranging from low-grade inflammation to immune exhaustion. While …

Fibroblast pathology in inflammatory joint disease

LJ Marsh, S Kemble, P Reis Nisa, R Singh… - Immunological …, 2021 - Wiley Online Library
Rheumatoid arthritis is an immune‐mediated inflammatory disease in which fibroblasts
contribute to both joint damage and inflammation. Fibroblasts are a major cell constituent of …

Clematichinenoside AR inhibits the pathology of rheumatoid arthritis by blocking the circPTN/miR-145-5p/FZD4 signal axis

X Wang, D Zhou, W Zhou, J Liu, Q Xue, Y Huang… - International …, 2022 - Elsevier
Abstract Backgrounds Traditional Chinese medicine roots and rhizomes of Clematis
chinensis Osbeck (CCO) has the effect of improving rheumatoid arthritis (RA) …

Long noncoding RNA/circular RNA regulates competitive endogenous RNA networks in rheumatoid arthritis: molecular mechanisms and traditional Chinese medicine …

J Wen, J Liu, L Wan, F Wang - Annals of medicine, 2023 - Taylor & Francis
Rheumatoid arthritis (RA) is a systemic and autoimmune disease that is mainly featured
abnormal fibroblast-like synoviocyte (FLS) proliferation and inflammatory cell infiltration …

Involvements of long noncoding RNAs in obesity‐associated inflammatory diseases

SN Wijesinghe, T Nicholson, K Tsintzas… - Obesity …, 2021 - Wiley Online Library
Obesity is associated with chronic low‐grade inflammation that affects the phenotype of
multiple tissues and therefore is implicated in the development and progression of several …