There has been an improvement in the blastocyst rates achieved following in-vitro embryo
production that can largely be attributed to improved embryo culture conditions based on an …

In mammalian and amphibian oocytes, the meiotic arrest at the G2/M transition is dependent
on cAMP regulation. Because genetic inactivation of a phosphodiesterase expressed in …

Cyclic adenosine monophosphate (cAMP) has been implicated as an important regulator of
meiotic maturation in mammalian oocytes. A decrease in cAMP, brought about by the action …

Introduction 3. Gonadotropins induce meiotic resumption via cumulus cells 3.1.
Gonadotropins regulate the level of cAMP in the oocyte via cumulus cells 3.2 …

The role of the cumulus cells in initiating the resumption of meiosis after exposure to
forskolin and dbcAMP was studied in the mouse. The resumption of meiosis was monitored …

Hypoxanthine is present in preparations of follicular fluid and has been shown to suppress
the spontaneous meiotic maturation of mammalian oocytes in vitro. The present experiments …

In vitro oocyte maturation (IVM) culture conditions have been relatively unchanged over the
past few decades and remain suboptimal. In contrast, studies of the in vivo environment …

The present study was conducted to investigate the direct action of hypoxanthine, which has
been reported to be present in pig follicular fluid, on spontaneous meiotic resumption of pig …

The purpose of this study was to examine the effects of an activator of AMPK (5‐
aminoimidazole‐4‐carboxamide 1‐β‐D‐ribofuranoside (AICAR)) on bovine oocyte nuclear …

This study evaluated the effect of forskolin and FSH on pig oocyte maturation when cultured
in a maturation inhibiting system. Ovaries from prepubertal gilts were collected at a local …