Increasingly, primary hypertension is being considered a syndrome and not a disease, with
the individual causes (diseases) having a common sign—an elevated blood pressure. To …

In the setting of primary aldosteronism, elevated aldosterone levels are associated with
increased blood pressure. Aldosterone concentrations within the normal range, however …

The underlying cause of resistant hypertension after adrenalectomy for primary
hyperaldosteronism remains controversial. The objective of this study was to identify …

BACKGROUND This study investigates the contribution of genetic interactions between the
β-2 adrenergic receptor (ADRB2) and nitric oxide synthase (NOS3) genes to the complex …

ABSTRACT Background: Aldosterone synthase (CYP11B2) is a key enzyme involved in the
terminal steps of aldosterone biosynthesis. Genetic variability in CYP11B2 gene has been …

Hypertension is one of the leading causes of death worldwide and the primary risk factor for
ischemic and hemorrhagic strokes and coronary artery disease. The role of aldosterone and …

Background: Genetic variations of renin-angiotensin-aldosterone system play an important
role in the pathogenesis of hypertension and stroke. Aim: To investigate the-344C/T and …

В обзоре представлены данные зарубежной и отечественной литературы о
патогенетической роли альдостерона, уровней альдостеронсинтазы и …

OBJECTIVE: The epistasis influence of vascular homeostasis genes is vital to multigenetic
diseases. This study was designed to perceive the possible role of epistasis in the etiology …

G protein‐coupled receptor kinase 4 (GRK4) with activating polymorphisms desensitize the
natriuric renal tubular D1 dopamine receptor, and these GRK4 polymorphisms are strongly …