Obesity is an epidemic problem in the world and is associated with several health problems,
including diabetes, cardiovascular disease, respiratory failure, muscle weakness, and …

Obstructive sleep apnea (OSA) is a prevalent sleep disorder considered as an independent
risk factor for cardiovascular consequences, such as systemic arterial hypertension …

Mechanisms linking obesity with upper airway dysfunction in obstructive sleep apnea are
reviewed. Obstructive sleep apnea is due to alterations in upper airway anatomy and …

Rationale: The effect of obesity on upper airway soft tissue structure and size was examined
in the New Zealand Obese (NZO) mouse and in a control lean mouse, the New Zealand …

Obesity is associated with alterations in upper airway collapsibility during sleep. Obese,
leptin-deficient mice demonstrate blunted ventilatory control, leading us to hypothesize that …

Obstructive sleep apnea (OSA) is a common disorder that describes recurrent collapse of
the upper airway during sleep. Animal models have been pivotal to the understanding of …

Sleep apnea is a common health concern that is characterized by repetitive episodes of
asphyxia. This condition has been linked to serious long-term adverse effects such as …

Obese leptin-deficient (ob/ob) mice demonstrate defects in upper airway structural and
neuromuscular control. We hypothesized that these defects predispose to upper airway …

Hypoglossal motoneurons are influenced by a variety of neuromodulators, some of which
change dynamically across sleep–wake states to alter motoneuron excitability and …

Abstract Study Objectives: Obesity is the most important risk factor for obstructive sleep
apnea (OSA), and the effects of obesity may be mediated by tongue fat. Our objective was to …