Molecular pathogenesis of Hodgkin's lymphoma: increasing evidence of the importance of the microenvironment
C Steidl, JM Connors, RD Gascoyne - Journal of Clinical Oncology, 2011 - ascopubs.org
Hodgkin's lymphoma (HL) represents the most common subtype of malignant lymphoma in
young people in the Western world. Most patients can be cured with modern treatment …
young people in the Western world. Most patients can be cured with modern treatment …
Role of the tumor microenvironment in regulating apoptosis and cancer progression
Apoptosis is a gene-directed program that is engaged to efficiently eliminate dysfunctional
cells. Evasion of apoptosis may be an important gate to tumor initiation and therapy …
cells. Evasion of apoptosis may be an important gate to tumor initiation and therapy …
The circuitry of the tumor microenvironment in adult and pediatric Hodgkin lymphoma: cellular composition, cytokine profile, EBV, and exosomes
Abstract Background: Classical Hodgkin lymphoma (cHL) is a unique lymphoid malignancy
with a tumor microenvironment (TME) consisting of a small number of neoplastic—Hodgkin …
with a tumor microenvironment (TME) consisting of a small number of neoplastic—Hodgkin …
T-cell responses to EBV
AD Hislop, GS Taylor - Epstein Barr Virus Volume 2: One Herpes Virus …, 2015 - Springer
Epstein–Barr virus (EBV) is arguably one of the most successful pathogens of humans,
persistently infecting over ninety percent of the world's population. Despite this high …
persistently infecting over ninety percent of the world's population. Despite this high …
Epidemiology of classical Hodgkin lymphoma and its association with Epstein Barr virus in Northern China
X Huang, I Nolte, Z Gao, H Vos, B Hepkema… - PLoS …, 2011 - journals.plos.org
Background The incidence of classical Hodgkin lymphoma (cHL) and its association with
Epstein-Barr virus (EBV) varies significantly with age, sex, ethnicity and geographic location …
Epstein-Barr virus (EBV) varies significantly with age, sex, ethnicity and geographic location …
The impact of HLA class I and EBV latency-II antigen-specific CD8+ T cells on the pathogenesis of EBV+ Hodgkin lymphoma
K Jones, L Wockner, RM Brennan… - Clinical & …, 2016 - academic.oup.com
In 40% of cases of classical Hodgkin lymphoma (cHL), Epstein–Barr virus (EBV) latency-II
antigens [EBV nuclear antigen 1 (EBNA1)/latent membrane protein (LMP) 1/LMP2A] are …
antigens [EBV nuclear antigen 1 (EBNA1)/latent membrane protein (LMP) 1/LMP2A] are …
Immune checkpoint inhibition in classical Hodgkin lymphoma
PS Pezeshki, M Eskian, MR Hamblin… - Expert Review of …, 2021 - Taylor & Francis
Introduction: Hodgkin lymphoma (HL) accounts for 10% of lymphoma cases every year. HL
is often curable by conventional chemotherapy and radiotherapy. However, in case of …
is often curable by conventional chemotherapy and radiotherapy. However, in case of …
Disease patterns in pediatric classical Hodgkin lymphoma: a report from a developing area in Brazil
MHM Barros, R Hassan… - Hematological oncology, 2011 - Wiley Online Library
Epidemiological patterns established about 20 years ago, divided classical Hodgkin
lymphoma (cHL) in three entities with regard to Epstein–Barr virus (EBV) status and …
lymphoma (cHL) in three entities with regard to Epstein–Barr virus (EBV) status and …
HLA-A* 02: 07 is a protective allele for EBV negative and a susceptibility allele for EBV positive classical Hodgkin lymphoma in China
X Huang, B Hepkema, I Nolte, K Kushekhar… - PLoS …, 2012 - journals.plos.org
HLA-A2 protects from EBV+ classical Hodgkin lymphoma (cHL) in Western Europe, but it is
unknown whether this protective effect also exists in the Chinese population. We …
unknown whether this protective effect also exists in the Chinese population. We …
HLA expression and HLA type associations in relation to EBV status in Hispanic Hodgkin lymphoma patients
LB Fletcher, RN Veenstra, EY Loo, AE Hwang… - PLoS …, 2017 - journals.plos.org
A proportion of classical Hodgkin lymphomas harbor the Epstein Barr virus (EBV). We
previously demonstrated that associations between Human Leukocyte Antigen (HLA) alleles …
previously demonstrated that associations between Human Leukocyte Antigen (HLA) alleles …