Injuries to the peripheral nerves result in partial or total loss of motor, sensory and autonomic
functions conveyed by the lesioned nerves to the denervated segments of the body, due to …

Gabapentin is an anti-epileptic agent but now it is also recommended as first line agent in
neuropathic pain, particularly in diabetic neuropathy and post herpetic neuralgia. α2δ-1, an …

Damage to the nervous system can cause neuropathic pain, which is in general poorly
treated and involves mechanisms that are incompletely known. Currently available animal …

Intractable neuropathic pain is a frequent consequence of nerve injury or disease. When
peripheral nerves are injured, damaged axons undergo Wallerian degeneration. Schwann …

Background Complex regional pain syndrome is a painful condition of unknown etiology.
Clinical and experimental observations suggest that limb immobilization may induce …

The balance between descending controls, both excitatory and inhibitory, can be altered in
various pain states. There is good evidence for a prominent α 2-adrenoceptor-mediated …

Opiates are among the most important drugs for treatment of moderate to severe pain and
prolonged opiate administration is often required to treat chronic pain states. We …

The past two decades have witnessed an exponential increase in research into cancer. This
effort, however, has not been translated into better perspectives as regards the problem …

After binding to the specific neurokinin-1 (NK-1) receptor, the peptide substance P (SP),
which is widely distributed in both the central and peripheral nervous systems, induces …

The effects of treatment with the anti‐convulsant agents, lamotrigine and riluzole were
compared with gabapentin in a rat experimental model of neuropathic pain. Rats were …