Rapid neck motions can load cervical nerve roots and produce persistent pain. This study
investigated the cellular basis of radicular pain and mechanical implications of tissue …

GABAB, μ‐opioid and adrenergic α2 receptors inhibit substance P release from primary
afferent terminals in the dorsal horn. Studies in cell expression systems suggest that μ …

Chemotherapy-induced peripheral neuropathy has an important impact on the quality of life
of cancer patients. Vincristine-induced neuropathy is a major dose-limiting side effect …

Nociceptive pain alerts the body to potential or actual tissue damage. By contrast,
neuropathic or" noninflammatory" pain, which results from injury to the nervous system …

Peripheral neuropathic pain arises from trauma to sensory nerves. Other types of acute
neurotrauma such as stroke and spinal cord injury are treated immediately, largely to …

Substance P (SP) is a neuropeptide that can modulate inflammatory mediator release
through activation of NK1 receptors (NK1R). Some studies have also suggested the …

It has been recently demonstrated that substance P (SP) and neurokinin-1 (NK-1) receptor
antagonists induce cell proliferation and cell inhibition in human melanoma cells …

Opiate analgesia in the spinal cord is impaired in diabetic neuropathic pain (DNP), but until
now the reason is unknown. We hypothesized that it resulted from a decreased inhibition of …

The study was undertaken to assess the antihyperalgesic effect of L-732,138,(N-acetyl-l-
tryptophan-3, 5-bistrifluoromethyl benzyl ester), a non-peptide neurokinin-1 (NK1) receptor …

Substance P (SP) and its receptor, the neurokinin 1 receptor (NK1R), play important roles in
transmitting and regulating somatosensory nociceptive information. However, their roles in …