Arterial stiffness results from a degenerative process affecting mainly the extracellular matrix
of elastic arteries under the effect of aging and risk factors. Changes in extracellular matrix …

Background: Arterial stiffness, the expression of reduced arterial elasticity, is an effective
predictor of cardiovascular disorders. Oxidative stress is an imbalance between exposure to …

The vascular system plays a central role in the transport of cells, oxygen and nutrients
between different regions of the body, depending on the needs, as well as of metabolic …

Oxidative stress and nitric oxide (NO) appear to represent important links between obesity
and cardiovascular, metabolic and/or renal disease. We investigated whether oxidative …

Perivascular adipose tissue (PVAT) is cushion of fat tissue surrounding blood vessels, which
is phenotypically different from other adipose tissue depots. PVAT is composed of …

The aim of the present study was to evaluate the effect of Compound 21 (C21), a selective
AT2R agonist, on the prevention of endothelial dysfunction, extracellular matrix (ECM) …

Background Obesity-related cardiovascular risk, end points, and mortality are strongly
related to arterial stiffening. Current therapeutic approaches for arterial stiffening are not …

We recently showed that Western diet–induced obesity and insulin resistance promotes
endothelial cortical stiffness in young female mice. Herein, we tested the hypothesis that …

Background and aims Early diagnosis of arteriosclerosis is fundamental for the prevention of
cardiovascular morbidity and mortality. The current study was performed to identify major …

Coffee and cocoa manufacturing produces large amounts of waste. Generated by-products
contain bioactive compounds with antioxidant and anti-inflammatory properties, suitable for …