[HTML][HTML] Small molecule metabolites: discovery of biomarkers and therapeutic targets

S Qiu, Y Cai, H Yao, C Lin, Y Xie, S Tang… - Signal Transduction and …, 2023 - nature.com
Metabolic abnormalities lead to the dysfunction of metabolic pathways and metabolite
accumulation or deficiency which is well-recognized hallmarks of diseases. Metabolite …

Omics approaches for the assessment of biological responses to nanoparticles

Y Abdelkader, L Perez-Davalos, R LeDuc… - Advanced Drug Delivery …, 2023 - Elsevier
Nanotechnology has enabled the development of innovative therapeutics, diagnostics, and
drug delivery systems. Nanoparticles (NPs) can influence gene expression, protein …

[HTML][HTML] The toxicity of nanoparticles and their interaction with cells: an in vitro metabolomic perspective

M Awashra, P Młynarz - Nanoscale Advances, 2023 - pubs.rsc.org
Nowadays, nanomaterials (NMs) are widely present in daily life due to their significant
benefits, as demonstrated by their application in many fields such as biomedicine …

[HTML][HTML] Silica nanoparticles aggravated the metabolic associated fatty liver disease through disturbed amino acid and lipid metabolisms-mediated oxidative stress

A Abulikemu, X Zhao, H Xu, Y Li, R Ma, Q Yao, J Wang… - Redox Biology, 2023 - Elsevier
The metabolic associated fatty liver disease (MAFLD) is a public health challenge, leading to
a global increase in chronic liver disease. The respiratory exposure of silica nanoparticles …

Prospects and hazards of silica nanoparticles: Biological impacts and implicated mechanisms

R Ding, Y Li, Y Yu, Z Sun, J Duan - Biotechnology Advances, 2023 - Elsevier
With the thrive of nanotechnology, silica nanoparticles (SiNPs) have been extensively
adopted in the agriculture, food, cosmetic, and even biomedical industries. Due to the mass …

Label-free MIP-SERS biosensor for sensitive detection of colorectal cancer biomarker

Y Lu, Q Liu, B Fu, P Li, W Xu - Talanta, 2023 - Elsevier
Early diagnosis of colorectal cancer can significantly improve the overall survival rate of
patients, thus selective and sensitive detection of biomarkers in serum samples is vital for …

[HTML][HTML] Short-term exposure to antimony induces hepatotoxicity and metabolic remodeling in rats

W Gu, R Pang, Y Chen, F Deng, M Zhang… - Ecotoxicology and …, 2023 - Elsevier
Antimony (Sb) poses a significant threat to human health due to sharp increases in its
exploitation and application globally, but few studies have explored the pathophysiological …

Proteomic profiling reveals dysregulated mitochondrial complex subunits responsible for myocardial toxicity induced by SiNPs

X Zhao, H Xu, Y Li, R Ma, Y Qi, M Zhang, C Guo… - Science of The Total …, 2023 - Elsevier
The relationship between environmental exposure to silica nanoparticles (SiNPs) and
adverse cardiac outcomes has received more attention. Our recent work has revealed a size …

Integration of proteomics and network toxicology reveals the mechanism of mercury chloride induced hepatotoxicity, in mice and HepG2 cells

X Cao, K Mao, Y Zhang, M Yang, H Liu, X Wang… - Food and Chemical …, 2023 - Elsevier
Mercury is one heavy metal toxin that could cause severe health impairments. Mercury
exposure has become a global environmental issue. Mercury chloride (HgCl 2) is one of …

The effects of short-term dietary exposure to SiO2 nanoparticle on the domesticated lepidopteran insect model silkworm (Bombyx mori): Evidence from the perspective …

X Zhang, W Shao, Y Huo, Y Kong, W Zhang, S Li… - Chemosphere, 2023 - Elsevier
Highlights•nSiO 2 exposure brought the midgut tissues damage.•nSiO 2 exposure impacted
the silkworm fitness and cocoon yields.•nSiO 2 exposure induced the differential expressed …