Primary tumors are known to constantly shed a large number of cancer cells into systemic
dissemination, yet only a tiny fraction of these cells is capable of forming overt metastases …

Malignancy affects the hemostatic system and the hemostatic system affects malignancy. In
cancer patients there are a number of coagulation abnormalities which provide the …

The mammary gland is composed of multiple types of epithelial cells, which are generated
by mammary stem cells (MaSCs) residing at the top of the hierarchy,. However, the …

The protein C pathway provides multiple important functions to maintain a regulated balance
between hemostasis and host defense systems in response to vascular and inflammatory …

Ovarian cancer is one of the most common gynecological malignancies, ranking third after
cervical and uterine cancer. High-grade serous ovarian cancer (HGSOC) is one of the most …

Independent of its well-known anticoagulation effects, activated protein C (APC) exhibits
pleiotropic cytoprotective properties. These include anti-inflammatory actions, anti …

Activated protein C (aPC) is a natural anticoagulant and a potent antiinflammatory and
cytoprotective agent. At the expense of increased bleeding risk aPC has been used–with …

Thrombin and hypoxia are important players in breast cancer progression. Breast cancers
often develop drug resistance, but mechanisms linking thrombin and hypoxia to drug …

Venous thromboembolism (VTE) is a preventable disease, yet it is one of the leading causes
of death among patients with cancer. Improving risk stratification mechanisms will allow us to …

Introduction Procoagulant factors promote cancer progression and metastasis. Protein C is
involved in hemostasis, inflammation and signal transduction, and has a protective effect on …