[HTML][HTML] Shear-dependent platelet aggregation: mechanisms and therapeutic opportunities

A Rana, E Westein, B Niego… - Frontiers in cardiovascular …, 2019 - frontiersin.org
Cardiovascular diseases (CVD) are the number one cause of morbidity and death
worldwide. As estimated by the WHO, the global death rate from CVD is 31% wherein, a …

Diabetes and antiplatelet therapy in acute coronary syndrome

JL Ferreiro, DJ Angiolillo - Circulation, 2011 - Am Heart Assoc
Cardiovascular disease, particularly coronary artery dis-ease resulting from accelerated
atherosclerosis, is the leading cause of morbidity and mortality in patients with diabetes …

Cilostazol: a review of basic mechanisms and clinical uses

RY Kherallah, M Khawaja, M Olson, D Angiolillo… - … drugs and therapy, 2022 - Springer
Primarily used in the treatment of intermittent claudication, cilostazol is a 2-oxyquinolone
derivative that works through the inhibition of phosphodiesterase III and related increases in …

Aspirin for primary cardiovascular risk prevention and beyond in diabetes mellitus

D Capodanno, DJ Angiolillo - Circulation, 2016 - Am Heart Assoc
Daily administration of low-dose aspirin has proved to be beneficial in preventing recurrent
cardiovascular events. However, the role of aspirin for primary prevention in patients with no …

Antiplatelet drugs: a review of their pharmacology and management in the perioperative period

R Hall, CD Mazer - Anesthesia & Analgesia, 2011 - journals.lww.com
In the normal course of the delivery of care, anesthesiologists encounter many patients who
are receiving drugs that affect platelet function as a fundamental part of primary and …

[HTML][HTML] In the presence of strong P2Y12 receptor blockade, aspirin provides little additional inhibition of platelet aggregation

PCJ Armstrong, PD Leadbeater, MV Chan… - Journal of Thrombosis …, 2011 - Elsevier
Background: Aspirin and antagonists of platelet ADP P2Y 12 receptors are often
coprescribed for protection against thrombotic events. However, blockade of platelet P2Y 12 …

Platelets and diabetes mellitus

F Santilli, P Simeone, R Liani, G Davì - Prostaglandins & other lipid …, 2015 - Elsevier
Platelet activation plays a key role in atherothrombosis in type 2 diabetes mellitus (T2DM)
and increased in vivo platelet activation with enhanced thromboxane (TX) biosynthesis has …

The evolution of antiplatelet therapy in the treatment of acute coronary syndromes: from aspirin to the present day

DJ Angiolillo - Drugs, 2012 - Springer
Our knowledge of the mechanisms of platelet-mediated thrombosis has increased
dramatically over the last 40 years. This increased understanding has identified treatment …

High rates of prasugrel and ticagrelor non-responder in patients treated with therapeutic hypothermia after cardiac arrest

K Ibrahim, M Christoph, S Schmeinck, K Schmieder… - Resuscitation, 2014 - Elsevier
Introduction After cardiac arrest due to acute coronary syndromes (ACS) therapeutic
hypothermia (HT) is the standard care to reduce neurologic damage. Additionally, the …

Personalised antiplatelet therapies for coronary artery disease: what the future holds

D Capodanno, DJ Angiolillo - European Heart Journal, 2023 - academic.oup.com
Coronary artery disease (CAD) is one of the leading causes of death globally, and
antiplatelet therapy is crucial for both its prevention and treatment. Antiplatelet drugs such as …