Microglia are the resident macrophages of the central nervous system. Microglia possess
varied morphologies and functions. Under normal physiological conditions, microglia mainly …

Glutamate is the major excitatory neurotransmitter in the central nervous system. Glutamate
transmission efficiency depends on the correct functionality and expression of a plethora of …

INTRODUCTION A reference atlas of human cell types is a major goal for the field. Here, we
set out to generate single-cell atlases of both gene expression (this study) and chromatin …

The immune and nervous systems have unique developmental trajectories that individually
build intricate networks of cells with highly specialized functions. These two systems have …

Glia constitute roughly half of the cells of the central nervous system (CNS) but were long-
considered to be static bystanders to its formation and function. Here we provide an …

Microglia are embryonically seeded macrophages that contribute to brain development,
homeostasis, and pathologies. It is thus essential to decipher how microglial properties are …

Microglia-astrocyte crosstalk has recently been at the forefront of glial research. Emerging
evidence illustrates that microglia-and astrocyte-derived signals are the functional …

Lipid droplets are dynamic intracellular lipid storage organelles that respond to the
physiological state of cells. In addition to controlling cell metabolism, they play a protective …

In the initiation or exacerbation of Alzheimer disease, the dissemination of oral
microorganisms into the brain tissue or the low‐level systemic inflammation have been …

Abstract Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder characterised
by deficits in social communication and restricted or repetitive behaviours. The clinical …