Pseudomonas aeruginosa adaptation and evolution in patients with cystic fibrosis

E Rossi, R La Rosa, JA Bartell, RL Marvig… - Nature Reviews …, 2021 - nature.com
Intense genome sequencing of Pseudomonas aeruginosa isolates from cystic fibrosis (CF)
airways has shown inefficient eradication of the infecting bacteria, as well as previously …

What makes a megaplasmid?

JPJ Hall, J Botelho, A Cazares… - … Transactions of the …, 2022 - royalsocietypublishing.org
Naturally occurring plasmids come in different sizes. The smallest are less than a kilobase of
DNA, while the largest can be over three orders of magnitude larger. Historically, research …

A megaplasmid family driving dissemination of multidrug resistance in Pseudomonas

A Cazares, MP Moore, JPJ Hall, LL Wright… - Nature …, 2020 - nature.com
Multidrug resistance (MDR) represents a global threat to health. Here, we used whole
genome sequencing to characterise Pseudomonas aeruginosa MDR clinical isolates from a …

Bacterial genome reductions: Tools, applications, and challenges

N LeBlanc, TC Charles - Frontiers in Genome Editing, 2022 - frontiersin.org
Bacterial cells are widely used to produce value-added products due to their versatility, ease
of manipulation, and the abundance of genome engineering tools. However, the efficiency of …

Comparative analysis of the core proteomes among the Pseudomonas major evolutionary groups reveals species-specific adaptations for Pseudomonas aeruginosa …

M Nikolaidis, D Mossialos, SG Oliver, GD Amoutzias - Diversity, 2020 - mdpi.com
The Pseudomonas genus includes many species living in diverse environments and hosts. It
is important to understand which are the major evolutionary groups and what are the …

Architecture of the biofilm-associated archaic Chaperone-Usher pilus CupE from Pseudomonas aeruginosa

J Böhning, AW Dobbelstein, N Sulkowski… - PLoS …, 2023 - journals.plos.org
Chaperone-Usher Pathway (CUP) pili are major adhesins in Gram-negative bacteria,
mediating bacterial adherence to biotic and abiotic surfaces. While classical CUP pili have …

[HTML][HTML] Niacinamide Antimicrobial Efficacy and Its Mode of Action via Microbial Cell Cycle Arrest

N Ziklo, M Bibi, L Sinai, P Salama - Microorganisms, 2024 - pmc.ncbi.nlm.nih.gov
Niacinamide is a versatile compound widely used in the personal care industry for its ample
skin benefits. As a precursor to nicotinamide adenine dinucleotide (NAD+), essential for ATP …

A loophole in soap dispensers mediates contamination with Gram‐negative bacteria

R Lucassen, N van Leuven, D Bockmühl - MicrobiologyOpen, 2023 - Wiley Online Library
Liquid soap dispensers are widely used in domestic and clinical settings. In previous
studies, the risk of bacterial contamination of refillable systems was pointed out and a …

Emergence of Carbapenem-Resistant ST244, ST292, and ST2446 Pseudomonas aeruginosa Clones in Burn Patients in Yunnan Province

Y Fang, Z Baloch, W Zhang, Y Hu, R Zheng… - Infection and drug …, 2022 - Taylor & Francis
Introduction The prevalence of carbapenem-resistant Pseudomonas aeruginosa is
increasing persistently, particularly in burn ward isolates. Here, we investigate the …

Epidemic territorial spread of IncP-2-type VIM-2 carbapenemase-encoding megaplasmids in nosocomial Pseudomonas aeruginosa populations

P Urbanowicz, I Bitar, R Izdebski… - Antimicrobial agents …, 2021 - Am Soc Microbiol
In 2003 to 2004, the first five VIM-2 metallo-β-lactamase (MBL)-producing Pseudomonas
aeruginosa (MPPA) isolates with an In4-like integron, In461 (aadB-bla VIM-2-aadA6), on …