Late-onset dementia is a major health concern in the ageing population. Alzheimer's
disease (AD) accounts for the largest proportion (65–70%) of dementia cases in the older …

In recent years we have witnessed a major interest in the study of the role of mitochondria,
not only as ATP producers through oxidative phosphorylation but also as regulators of …

Objective Although the underlying cause of Huntington's disease (HD) is well established,
the actual pathophysiological processes involved remain to be fully elucidated. In other …

The etiology of Alzheimer's disease (AD) remains unclear. The emerging view is that
cerebrovascular dysfunction is a feature not only of cerebrovascular diseases, such as …

ATM is one of the sentries at the gate of genome stability. This multifunctional protein kinase
orchestrates the intricate array of cellular responses to DNA double-strand breaks. Absence …

Although much maligned, the amyloid-β (Aβ) protein has been shown to possess a number
of trophic properties that emanate from the protein's ability to bind Cu, Fe and Zn. Aβ …

Alzheimer's disease (AD) brain reveals high rates of oxygen consumption and oxidative
stress, altered antioxidant defences, increased oxidized polyunsaturated fatty acids, and …

Diseases of the central nervous system (CNS) pose a significant health challenge, but
despite their diversity, they share many common features and mechanisms. For example …

Alzheimer's disease (AD) is characterized by deposition of amyloid-ß (Aß) plaques within the
brain parenchyma followed by synaptic loss and neuronal death. Deposited Aß reacts with …

Amyloid-β peptide (Aβ) is a central player in the pathogenesis and diagnosis of Alzheimer
disease. It aggregates to form the core of Alzheimer disease-associated plaques found in …