Neuropathic pain caused by a lesion or disease of the somatosensory nervous system is a
common chronic pain condition with major impact on quality of life. Examples include …

The previous decade has seen a rapid increase in microglial studies on pain, with a unique
focus on microgliosis in the spinal cord after nerve injury and neuropathic pain. Numerous …

Sensory neurons of the dorsal root ganglion (DRG) are critical for maintaining tissue
homeostasis by sensing and initiating responses to stimuli. While most preclinical studies of …

The sense of touch is fundamental as it provides vital, moment-to-moment information about
the nature of our physical environment. Primary sensory neurons provide the basis for this …

Sensory fibers of the peripheral nervous system carry sensation from specific sense
structures or use different tissues and organs as receptive fields, and convey this information …

Social touch—the affiliative skin-to-skin contact between individuals—can rapidly evoke
emotions of comfort, pleasure, or calm, and is essential for mental and physical well-being …

Patients with bi-allelic loss of function mutations in the voltage-gated sodium channel Nav1.
7 present with congenital insensitivity to pain (CIP), whilst low threshold mechanosensation …

Unmyelinated low-threshold mechanoreceptors (C-tactile, CT) in the human skin are
important for signaling information about hedonic aspects of touch. We have previously …

Pain, whether acute or persistent, is a serious medical problem worldwide. However, its
management remains unsatisfactory, and new analgesic molecules are required. We show …

TAFA chemokine like family member 4 (TAFA4, also named FAM19A4) is a member of the
TAFA chemokine like ligand or FAM19A family, which includes TAFA1, TAFA2, TAFA3 …