Sensitization of spinal nociceptive circuits plays a crucial role in neuropathic pain. This
sensitization depends on new gene expression that is primarily regulated via transcriptional …

Sensory neurons of the dorsal root ganglion (DRG) play a crucial role in maintaining tissue
homeostasis by sensing and initiating responses to stimuli. While most preclinical studies of …

摘要触觉是一种重要的躯体感觉, 除在物体识别和环境感知中发挥作用之外,
其在情感交流方面的作用亦十分重要. C 类低阈值机械感受器(C-type low threshold …

Pain is an unpleasant sensation and emotional experience elicited by potentially harmful
stimulations to protect the integrity of the body. An endogenous mechanism involving the …

Pleasurable touch during social behavior is key to building familial bonds and meaningful
connections. As revealed by a global pandemic, isolation from these social contacts can …

The mechanisms of neuropathic pain after spinal cord injury (SCI) are not fully understood.
In addition to the plasticity that occurs within the injured spinal cord, peripheral processes …

Chronic pain is a debilitating condition that affects up to 20-25% of the population
worldwide. Given its complexity, it is notoriously difficult to treat. The rise in the opioid …

The ability to experience pain is essential for survival and wellbeing and the pathological
consequences of the inability to experience pain are particularly well‐illustrated by the …

La douleur est l'une des premières causes de consultation médicale. Une partie importante
de la population souffre de douleurs articulaires chroniques et sollicite des soins médicaux …

Cutaneous mechanoreceptors are a morphologically and functionally diverse class of
primary sensory neurons in mammals that transduce mechanical stimuli acting on the skin …