Pharmacological properties and derivatives of shikonin—A review in recent years
C Guo, J He, X Song, L Tan, M Wang, P Jiang… - Pharmacological …, 2019 - Elsevier
Shikonin is the major bioactive component extracted from the roots of Lithospermum
erythrorhizon which is also known as “Zicao” in Traditional Chinese Medicine (TCM). Recent …
erythrorhizon which is also known as “Zicao” in Traditional Chinese Medicine (TCM). Recent …
[HTML][HTML] Progress in targeting PTEN/PI3K/Akt axis in glioblastoma therapy: Revisiting molecular interactions
Glioblastoma (GBM) is one of the most malignant cancers of central nervous system and due
to its sensitive location, surgical resection has high risk and therefore, chemotherapy and …
to its sensitive location, surgical resection has high risk and therefore, chemotherapy and …
Naphthoquinones and derivatives as potential anticancer agents: An updated review
One of the leading global causes of death is cancer; even though several treatment methods
have improved survival rates, the incidence and fatality rates remain high. Naphthoquinones …
have improved survival rates, the incidence and fatality rates remain high. Naphthoquinones …
[HTML][HTML] A critical review on quercetin bioflavonoid and its derivatives: scope, synthesis, and biological applications with future prospects
S Dhanaraj - Arabian Journal of Chemistry, 2023 - Elsevier
Lifestyle is an important factor in health, and researchers are trying to see the adverse effect
on human health of a change in lifestyle. Many people follow unhealthy lifestyles, which …
on human health of a change in lifestyle. Many people follow unhealthy lifestyles, which …
Anti-angiogenic effect of Shikonin in rheumatoid arthritis by downregulating PI3K/AKT and MAPKs signaling pathways
C Liu, L He, J Wang, Q Wang, C Sun, Y Li, K Jia… - Journal of …, 2020 - Elsevier
Ethnopharmacological relevance Zicao is the dried root of Lithospermum erythrorhizon Sieb,
et Zucc, Arnebia euchroma (Royle) Johnst, or Arnebia guttata Bunge and commonly used to …
et Zucc, Arnebia euchroma (Royle) Johnst, or Arnebia guttata Bunge and commonly used to …
ACT001, a novel PAI-1 inhibitor, exerts synergistic effects in combination with cisplatin by inhibiting PI3K/AKT pathway in glioma
X Xi, N Liu, Q Wang, Y Chu, Z Yin, Y Ding, Y Lu - Cell Death & Disease, 2019 - nature.com
PAI-1 plays significant roles in cancer occurrence, relapse and multidrug resistance and is
highly expressed in tumours. ACT001, which is currently in phase I clinical trials for the …
highly expressed in tumours. ACT001, which is currently in phase I clinical trials for the …
Synthesis, biological function and evaluation of Shikonin in cancer therapy
F Wang, X Yao, Y Zhang, J Tang - Fitoterapia, 2019 - Elsevier
Shikonin is a natural compound isolated from herbs and traditional medicines that have
been used in a number of countries to treat various illnesses including inflammation, virus …
been used in a number of countries to treat various illnesses including inflammation, virus …
Fucoxanthin activates apoptosis via inhibition of PI3K/Akt/mTOR pathway and suppresses invasion and migration by restriction of p38-MMP-2/9 pathway in human …
Y Liu, J Zheng, Y Zhang, Z Wang, Y Yang, M Bai… - Neurochemical …, 2016 - Springer
Fucoxanthin is rich in seaweed and considered as effective anti-cancer drug because of
powerful antioxidant properties. The objective of this study was to investigate the role of …
powerful antioxidant properties. The objective of this study was to investigate the role of …
[HTML][HTML] Natural bioactive molecules: An alternative approach to the treatment and control of glioblastoma multiforme
P Tagde, P Tagde, S Tagde, T Bhattacharya… - Biomedicine & …, 2021 - Elsevier
Glioblastoma multiforme is one of the most deadly malignant tumors, with more than 10,000
cases recorded annually in the United States. Various clinical analyses and studies show …
cases recorded annually in the United States. Various clinical analyses and studies show …
[HTML][HTML] Natural products: A hope for glioblastoma patients
Glioblastoma (GBM) is one of the most aggressive malignant tumors with an overall dismal
survival averaging one year despite multimodality therapeutic interventions including …
survival averaging one year despite multimodality therapeutic interventions including …