Single-cell RNA sequencing in cardiovascular development, disease and medicine
Advances in single-cell RNA sequencing (scRNA-seq) technologies in the past 10 years
have had a transformative effect on biomedical research, enabling the profiling and analysis …
have had a transformative effect on biomedical research, enabling the profiling and analysis …
[HTML][HTML] Mitochondrial-targeted therapy for doxorubicin-induced cardiotoxicity
Anthracyclines, such as doxorubicin, are effective chemotherapeutic agents for the treatment
of cancer, but their clinical use is associated with severe and potentially life-threatening …
of cancer, but their clinical use is associated with severe and potentially life-threatening …
[PDF][PDF] Progress in multicellular human cardiac organoids for clinical applications
Advances in self-organizing cardiac organoids to recapitulate human cardiogenesis have
provided a powerful tool for unveiling human cardiac development, studying cardiovascular …
provided a powerful tool for unveiling human cardiac development, studying cardiovascular …
[PDF][PDF] SARS-CoV-2 infects human pluripotent stem cell-derived cardiomyocytes, impairing electrical and mechanical function
S Marchiano, TY Hsiang, A Khanna, T Higashi… - Stem cell reports, 2021 - cell.com
COVID-19 patients often develop severe cardiovascular complications, but it remains
unclear if these are caused directly by viral infection or are secondary to a systemic …
unclear if these are caused directly by viral infection or are secondary to a systemic …
Cellular and engineered organoids for cardiovascular models
An ensemble of in vitro cardiac tissue models has been developed over the past several
decades to aid our understanding of complex cardiovascular disorders using a reductionist …
decades to aid our understanding of complex cardiovascular disorders using a reductionist …
Highlights on advancing frontiers in tissue engineering
The field of tissue engineering continues to advance, sometimes in exponential leaps
forward, but also sometimes at a rate that does not fulfill the promise that the field imagined a …
forward, but also sometimes at a rate that does not fulfill the promise that the field imagined a …
SGLT2 inhibitor ameliorates endothelial dysfunction associated with the common ALDH2 alcohol flushing variant
The common aldehyde dehydrogenase 2 (ALDH2) alcohol flushing variant known as
ALDH2* 2 affects∼ 8% of the world's population. Even in heterozygous carriers, this …
ALDH2* 2 affects∼ 8% of the world's population. Even in heterozygous carriers, this …
[HTML][HTML] Revolutionizing disease Modeling: the emergence of organoids in cellular systems
R Silva-Pedrosa, AJ Salgado, PE Ferreira - Cells, 2023 - mdpi.com
Cellular models have created opportunities to explore the characteristics of human diseases
through well-established protocols, while avoiding the ethical restrictions associated with …
through well-established protocols, while avoiding the ethical restrictions associated with …
[HTML][HTML] Exploring the promising potential of induced pluripotent stem cells in cancer research and therapy
M Chehelgerdi, F Behdarvand Dehkordi… - Molecular Cancer, 2023 - Springer
The advent of iPSCs has brought about a significant transformation in stem cell research,
opening up promising avenues for advancing cancer treatment. The formation of cancer is a …
opening up promising avenues for advancing cancer treatment. The formation of cancer is a …
[HTML][HTML] Modeling cardiac disease mechanisms using induced pluripotent stem cell-derived cardiomyocytes: progress, promises and challenges
Cardiovascular diseases (CVDs) are a class of disorders affecting the heart or blood
vessels. Despite progress in clinical research and therapy, CVDs still represent the leading …
vessels. Despite progress in clinical research and therapy, CVDs still represent the leading …