[HTML][HTML] Intranasal drug delivery: Opportunities and toxicologic challenges during drug development
LA Keller, O Merkel, A Popp - Drug delivery and translational research, 2021 - Springer
Over the past 10 years, the interest in intranasal drug delivery in pharmaceutical R&D has
increased. This review article summarises information on intranasal administration for local …
increased. This review article summarises information on intranasal administration for local …
Is oxytocin “nature's medicine”?
Oxytocin is a pleiotropic, peptide hormone with broad implications for general health,
adaptation, development, reproduction, and social behavior. Endogenous oxytocin and …
adaptation, development, reproduction, and social behavior. Endogenous oxytocin and …
[HTML][HTML] Advances in human oxytocin measurement: challenges and proposed solutions
Oxytocin, a neuropeptide known for its role in reproduction and socioemotional processes,
may hold promise as a therapeutic agent in treating social impairments in patient …
may hold promise as a therapeutic agent in treating social impairments in patient …
[HTML][HTML] Advances in the field of intranasal oxytocin research: lessons learned and future directions for clinical research
DS Quintana, A Lischke, S Grace, D Scheele… - Molecular …, 2021 - nature.com
Reports on the modulatory role of the neuropeptide oxytocin on social cognition and
behavior have steadily increased over the last two decades, stimulating considerable …
behavior have steadily increased over the last two decades, stimulating considerable …
Oxytocin and the neurobiology of prosocial behavior
Humans are an unusually prosocial species, who engage in social behaviors that include
altruism—whereby an individual engages in costly or risky acts to improve the welfare of …
altruism—whereby an individual engages in costly or risky acts to improve the welfare of …
Salivary and plasmatic oxytocin are not reliable trait markers of the physiology of the oxytocin system in humans
Single measurements of salivary and plasmatic oxytocin are used as indicators of the
physiology of the oxytocin system. However, questions remain about whether they are …
physiology of the oxytocin system. However, questions remain about whether they are …
Oxytocin—a social peptide? Deconstructing the evidence
In this paper, we analyse the claim that oxytocin is a 'social neuropeptide'. This claim
originated from evidence that oxytocin was instrumental in the initiation of maternal …
originated from evidence that oxytocin was instrumental in the initiation of maternal …
Infrequent intranasal oxytocin followed by positive social interaction improves symptoms in autistic children: a pilot randomized clinical trial
Introduction: There are currently no approved drug interventions for social behavior
dysfunction in autism spectrum disorder (ASD). Previous trials investigating effects of daily …
dysfunction in autism spectrum disorder (ASD). Previous trials investigating effects of daily …
What's Love Got to do with it: Role of oxytocin in trauma, attachment and resilience
Oxytocin (OT) is a neurohypophysial hormone and neuropeptide produced by the
hypothalamus and released by the pituitary gland. It has multiple physiological roles …
hypothalamus and released by the pituitary gland. It has multiple physiological roles …
[HTML][HTML] Nasal oxytocin for the treatment of psychiatric disorders and pain: achieving meaningful brain concentrations
DC Yeomans, LR Hanson, DS Carson… - Translational …, 2021 - nature.com
There is evidence of the therapeutic potential of intranasal oxytocin for the treatment of pain
and various psychiatric disorders, however, there is scant evidence that oxytocin reaches …
and various psychiatric disorders, however, there is scant evidence that oxytocin reaches …