Loss of the metabolism and sleep regulating neuronal populations expressing orexin and oxytocin in the hypothalamus in amyotrophic lateral sclerosis
Aims To determine the underlying cellular changes and clinical correlates associated with
pathology of the hypothalamus in amyotrophic lateral sclerosis (ALS), as hypothalamic …
pathology of the hypothalamus in amyotrophic lateral sclerosis (ALS), as hypothalamic …
Effects of intranasal administration of oxytocin and vasopressin on social cognition and potential routes and mechanisms of action
S Yao, KM Kendrick - Pharmaceutics, 2022 - mdpi.com
Acute and chronic administration of intranasal oxytocin and vasopressin have been
extensively utilized in both animal models and human preclinical and clinical studies over …
extensively utilized in both animal models and human preclinical and clinical studies over …
Convolutions in the rendition of nose to brain therapeutics from bench to bedside: Feats & fallacies
Brain, a subtle organ of multifarious nature presents plethora of physiological, metabolic and
bio-chemical convolutions that impede the delivery of biomolecules and thereby resulting in …
bio-chemical convolutions that impede the delivery of biomolecules and thereby resulting in …
What's Love Got to do with it: Role of oxytocin in trauma, attachment and resilience
Oxytocin (OT) is a neurohypophysial hormone and neuropeptide produced by the
hypothalamus and released by the pituitary gland. It has multiple physiological roles …
hypothalamus and released by the pituitary gland. It has multiple physiological roles …
In the nose or on the tongue? Contrasting motivational effects of oral and intranasal oxytocin on arousal and reward during social processing
Intranasal oxytocin exerts wide-ranging effects on socioemotional behavior and is proposed
as a potential therapeutic intervention in psychiatric disorders. However, following intranasal …
as a potential therapeutic intervention in psychiatric disorders. However, following intranasal …
A randomized trial shows dose-frequency and genotype may determine the therapeutic efficacy of intranasal oxytocin
BackgroundThe neuropeptide oxytocin is proposed as a promising therapy for social
dysfunction by modulating amygdala-mediated social-emotional behavior. Although clinical …
dysfunction by modulating amygdala-mediated social-emotional behavior. Although clinical …
Nasal oxytocin for the treatment of psychiatric disorders and pain: achieving meaningful brain concentrations
DC Yeomans, LR Hanson, DS Carson… - Translational …, 2021 - nature.com
There is evidence of the therapeutic potential of intranasal oxytocin for the treatment of pain
and various psychiatric disorders, however, there is scant evidence that oxytocin reaches …
and various psychiatric disorders, however, there is scant evidence that oxytocin reaches …
Using nanotechnology to deliver biomolecules from nose to brain—peptides, proteins, monoclonal antibodies and RNA
ML Borrajo, MJ Alonso - Drug delivery and translational research, 2022 - Springer
There is a growing number of biomolecules, including peptides, proteins, monoclonal
antibodies and RNA, that could be potentially used for the treatment of central nervous …
antibodies and RNA, that could be potentially used for the treatment of central nervous …
Oxytocin has 'tend-and-defend'functionality in group conflict across social vertebrates
Z Triki, K Daughters… - … Transactions of the …, 2022 - royalsocietypublishing.org
Across vertebrate species, intergroup conflict confronts individuals with a tension between
group interests best served by participation in conflict and personal interest best served by …
group interests best served by participation in conflict and personal interest best served by …
Intranasal administration for pain: oxytocin and other polypeptides
Pain, particularly chronic pain, remains one of the most debilitating and difficult-to-treat
conditions in medicine. Chronic pain is difficult to treat, in part because it is associated with …
conditions in medicine. Chronic pain is difficult to treat, in part because it is associated with …