Aging induces structural and functional changes in the heart that are associated with
increased risk of cardiovascular disease and impaired functional capacity in the elderly …

Cardiovascular disease is the main cause of death globally, accounting for over 17 million
deaths each year. As the incidence of cardiovascular disease rises markedly with age, the …

The isolated retrograde-perfused Langendorff heart and the isolated ejecting heart have,
over many decades, resulted in fundamental discoveries that form the underpinnings of our …

Background—Oxidant stress has been implicated in the pathogenesis of atherothrombosis
and other vascular disorders accompanied by endothelial dysfunction. Glutathione …

Aging of the heart is associated with a blunted response to sympathetic stimulation, reduced
contractility, and increased propensity for arrhythmias, with the risk of sudden cardiac death …

Impaired myocardial Ca2+ cycling is a critical contributor to the development of heart failure
(HF), causing changes in the contractile function and structure remodeling of the heart …

Background A hallmark of aging of the cardiac myocyte is impaired sarcoplasmic reticulum
(SR) calcium uptake and relaxation due to decreased SR calcium ATP ase (SERCA) activity …

Diastolic dysfunction in the aging heart is a grave condition that challenges the life and
lifestyle of a growing segment of our population. This report seeks to examine the role and …

Western societies are rapidly aging, and cardiovascular diseases are the leading cause of
death. In fact, age and cardiovascular diseases are positively correlated, and disease …

Age-related skeletal muscle sarcopenia has been extensively studied and smooth muscle
sarcopenia has been recently described, but age-related cardiac sarcopenia has not been …