Estrogen receptors (ERs) regulate multiple complex physiological processes in humans.
Abnormal ER signaling may result in various disorders, including reproductive system …

The estrogen receptor (ER) has functionality in selected ovarian cancer subtypes and
represents a potential target for therapy. The majority (> 80%) of high grade serous, low …

Estrogen mainly binds to estrogen receptors (ERs) to regulate menstrual cycles and
reproduction. The expression of ERalpha (ERα), ERbeta (ERβ), and G-protein-coupled …

Cancer is a major public health issue and represents the second leading cause of death in
women worldwide, as female reproductive-related neoplasms are the main cause of …

Estrogens have been implicated in the pathogenesis of various cancer types, including
colorectal carcinoma (CRC). Estrogen receptors such as ERα and ERβ activate intracellular …

Estrogens play important roles in the development and progression of multiple tumor types.
Accumulating evidence points to the significance of estrogen action not only in tumors of …

Ovarian cancer is one of the most common cancers in women and the most concerning
issues in gynecological oncology in recent years. It is postulated that many factors may …

Cancer is one of the most common causes of death worldwide, and its development is a
result of the complex interaction of genetic factors, environmental cues, and aging. Hormone …

Gynecological malignancies are a female type of cancers that affects the reproductive
system. Cancer metastasis or recurrence mediated by cellular invasiveness occurs at …

Obesity is a complex disease and a global epidemic. It is a risk factor for other chronic
diseases including breast cancer, especially in women after menopause. Diverse etiologies …