Cancer is the second leading cause of death worldwide. The main modality to fight against
cancer is surgery, radiotherapy, and chemotherapy, and more recently targeted therapy …

Applications of genomics to population screening are expanding in the United States and
internationally. Many of these programs are being implemented in the context of healthcare …

Identification of deleterious variants in hereditary breast and ovarian cancer (HBOC)
susceptibility genes allows for increased clinical surveillance and early detection, and could …

BRCA genes are important for the integrity and stability of genetic material and play key
roles in repairing DNA breaks via high fidelity homologous recombination. BRCA mutations …

Hereditary breast and ovarian cancer syndrome is caused by germline mutations in
BRCA1/2 genes. These genes are very large and their mutations are heterogeneous and …

Background This study aimed to evaluate the implementation of the population-and family
history (FH)-based screening for BReast CAncer (BRCA) in Iran, a country where less than …

BRCA mutation carriers face various situations that influence their fertility potential. There is
still a lack of guideline or expert consensus on Fertility Preservation (FP) in BRCA mutation …

Background Mutated BRCA1/2 genes are associated with hereditary breast and ovarian
cancer (HBOC). So far most of the identified BRCA1/2 pathogenic variants are single …

The aim of this study was to identify the frequency and spectrum of germline BRCA1/2
pathogenic alterations in a cohort of patients with breast carcinoma. In this study, a total of …

Abstract Knowledge of population specific BRCA1/2 founder mutations provides a valuable
and cost‐effective genetic testing strategy. Twenty‐three recurrent BRCA1 mutations have …