[HTML][HTML] Dynamics of viral and host 3D genome structure upon infection

MJ Friedman, H Lee, YC Kwon, S Oh - Journal of Microbiology and …, 2022 - ncbi.nlm.nih.gov
Eukaryotic chromatin is highly organized in the 3D nuclear space and dynamically regulated
in response to environmental stimuli. This genomic organization is arranged in a …

Multiple roles of Brd4 in the infectious cycle of human papillomaviruses

AA McBride, A Warburton, S Khurana - Frontiers in Molecular …, 2021 - frontiersin.org
Human Papillomaviruses (HPV) reproduce in stratified epithelia by establishing a reservoir
of low-level infection in the dividing basal cells and restricting the production of viral particles …

Structure and transcription of integrated HPV DNA in vulvar carcinomas

A Van Arsdale, L Turker, YC Chang, J Gould… - npj Genomic …, 2024 - nature.com
HPV infections are associated with a fraction of vulvar cancers. Through hybridization
capture and DNA sequencing, HPV DNA was detected in five of thirteen vulvar cancers …

HPV integration and cervical cancer: a failed evolutionary viral trait

MA Molina, RDM Steenbergen, A Pumpe… - Trends in molecular …, 2024 - cell.com
Countless efforts have been made to eradicate cervical cancer worldwide, including
improving disease screening and human papillomavirus (HPV) vaccination programs …

Oral microbiota-driven cell migration in carcinogenesis and metastasis

H Bai, J Yang, S Meng, C Liu - Frontiers in Cellular and Infection …, 2022 - frontiersin.org
The oral cavity harbors approximately 1,000 microbial species, and both pathogenic and
commensal strains are involved in the development of carcinogenesis by stimulating chronic …

How chaotic is genome chaos?

JA Shapiro - Cancers, 2021 - mdpi.com
Simple Summary Cancer genomes can undergo major restructurings involving many
chromosomal locations at key stages in tumor development. This restructuring process has …

Pathogenic role of immune evasion and integration of human papillomavirus in oropharyngeal cancer

T Hatano, D Sano, H Takahashi, N Oridate - Microorganisms, 2021 - mdpi.com
The incidence of oropharyngeal cancer (OPC) is increasing remarkably among all head and
neck cancers, mainly due to its association with the human papillomavirus (HPV). Most …

CDK7 inhibitor suppresses tumor progression through blocking the cell cycle at the G2/M phase and inhibiting transcriptional activity in cervical cancer

S Zhong, Y Zhang, X Yin, W Di - OncoTargets and therapy, 2019 - Taylor & Francis
Background The disordered cell cycle and dysregulated expression of numerous
oncogenes involved in tumor-relevant processes are highly related to the tumorigenesis of …

[HTML][HTML] Differences in integration frequencies and APOBEC3 profiles of five high-risk HPV types adheres to phylogeny

AH Løvestad, A Repesa, JM Costanzi, S Lagström… - Tumour Virus …, 2022 - Elsevier
Abstract Persistent infection with Human Papillomavirus (HPV) is responsible for almost all
cases of cervical cancers, and HPV16 and HPV18 associated with the majority of these …

Uncovering the role of the E1 protein in different stages of human papillomavirus 18 genome replication

A Piirsoo, M Kala, E Sankovski, M Ustav… - Journal of …, 2020 - Am Soc Microbiol
The life cycle of human papillomaviruses (HPVs) comprises three distinct phases of DNA
replication: initial amplification, maintenance of the genome copy number at a constant level …