The TGF-β ligand superfamily contains at least 40 members, many of which are produced
and act within the mammalian testis to facilitate formation of sperm. Their progressive …

Mammalian male germ cell development is a stepwise cell-fate transition process; however,
the full-term developmental profile of male germ cells remains undefined. Here, by …

The divergence of distinct cell populations from multipotent progenitors is poorly understood,
particularly in vivo. The gonad is an ideal place to study this process, because it originates …

Little is known about the metabolic profile of cumulus-oocyte complexes (COCs) during
maturation. The aim of this study was to determine the differential participation of enzymatic …

Sexual reproduction is crucially dependent on meiosis, a conserved, specialized cell
division programme that is essential for the production of haploid gametes. Here we …

XX female gonadal dysgenesis (XX-GD) is a rare, genetically heterogeneous disorder
characterized by lack of spontaneous pubertal development, primary amenorrhea, uterine …

Despite the importance of germ cell (GC) differentiation for sexual reproduction, the gene
networks underlying their fate remain unclear. Here, we comprehensively characterize the …

The body of knowledge surrounding reproductive development spans the fields of genetics,
anatomy, physiology and biomedicine, to build a comprehensive understanding of the later …

Mammalian sex determination hinges on sexually dimorphic transcriptional programs in
developing fetal gonads. A comprehensive view of these programs is crucial for …

In mouse embryos at mid-gestation, primordial germ cells (PGCs) undergo licensing to
become gametogenesis-competent cells (GCCs), gaining the capacity for meiotic initiation …