Müller glial cells ensheath all retinal neurons in vertebrate retinae. There are a multitude of
functional interactions between neurons and Müller cells, including delivery of the light …

purpose. Lutein has been the focus of recent study as a possible therapeutic approach for
retinal diseases, but the molecular mechanism of its neuroprotective effect remains to be …

Members of the interleukin‐6 cytokine family, including leukemia inhibitory factor (LIF),
signal through gp130. The neuroprotective role of gp130 activation has been widely …

Retinal degeneration is a major cause of severe visual impairment or blindness.
Understanding the underlying molecular mechanisms is a prerequisite to develop …

Identifying the trophic factors for retina photoreceptors and the intracellular pathways
activated to promote cell survival is crucial for treating retina neurodegenerative diseases …

The rd1 mouse is a relevant model for studying the mechanisms of photoreceptor
degeneration in retinitis pigmentosa. Treatment with ciliary neurotrophic factor (CNTF) in …

We have recently demonstrated that neural stem cell-based intravitreal co-administration of
glial cell line-derived neurotrophic factor (GDNF) and ciliary neurotrophic factor (CNTF) …

Purpose Expression of leukemia inhibitory factor (LIF) by a subset of Müller glia cells has
recently been implicated in an endogenous survival response to photoreceptor injury in a …

Ciliary neurotrophic factor (CNTF) is primarily known for its important cellular effects within
the nervous system. However, recent studies indicate that its receptor can be highly …

purpose. To assess neurotrophic factor upregulation in the retina after damage to the optic
nerve and relate that regulation to changes in photoreceptor stability and function. methods …