Head and neck cancer (HNC) is malignant, genetically complex and difficult to treat and is
the sixth most frequent cancer, with tobacco, alcohol and human papillomavirus being major …

Oral cancer is the most common form of head and neck squamous cell carcinoma (HNSCC)
and most frequently presents as oral squamous cell carcinoma (OSCC), which is associated …

Abstract Background Tumor-associated macrophages (TAMs) have a leading position in the
tumor microenvironment. Previously, we have demonstrated that M1-like TAMs activated by …

The family of mammalian E2F transcription factors (E2Fs) comprise of 8 members (E2F1-
E2F8) classified as activators (E2F1-E2F3) and repressors (E2F4-E2F8) primarily regulating …

In heterogeneous head and neck cancer (HNC), subtype-specific treatment regimens are
currently missing. An integrated analysis of patient HNC subtypes using single-cell …

Simple Summary Next-generation sequencing of head and neck squamous cell carcinoma
has revealed multiple new gene mutations, while simultaneously confirming the role of …

Simple Summary In this article, we outline updates on the current relevance of tumor
budding (TB) and partial epithelial–mesenchymal transition (p-EMT), both as a prognostic …

This study aimed to develop an in vitro three-dimensional (3D) cell culture model of oral
carcinogenesis for the rapid, scalable testing of chemotherapeutic agents. Spheroids of …

Head and neck cancer (HNC) is the sixth most common type of cancer, with more than half a
million new cases annually. This review focuses on the role of oral dysbiosis and HPV …

Head and neck squamous cell carcinoma (HNSCC) are among the well-known neoplasms
originating in the oral cavity, pharynx, and larynx. Despite advancements in chemotherapy …