Human neutrophils uniquely release TIMP-free MMP-9 to provide a potent catalytic stimulator of angiogenesis

VC Ardi, TA Kupriyanova… - Proceedings of the …, 2007 - National Acad Sciences
Several lines of evidence have implicated matrix metalloproteinase 9 (MMP-9) as a protease
inducing an angiogenic switch critical for tumor progression. Among MMP-9-expressing cell …

Tuberculous granuloma induction via interaction of a bacterial secreted protein with host epithelium

HE Volkman, TC Pozos, J Zheng, JM Davis, JF Rawls… - Science, 2010 - science.org
Granulomas, organized aggregates of immune cells, are a hallmark of tuberculosis and
have traditionally been thought to restrict mycobacterial growth. However, analysis of …

Biomimetic nanoengineered scaffold for enhanced full-thickness cutaneous wound healing

N Zandi, B Dolatyar, R Lotfi, Y Shallageh… - Acta biomaterialia, 2021 - Elsevier
Wound healing is a complex process based on the coordinated signaling molecules and
dynamic interactions between the engineered scaffold and newly formed tissue. So far, most …

MMP-2, MT1-MMP, and TIMP-2 are essential for the invasive capacity of human mesenchymal stem cells: differential regulation by inflammatory cytokines

C Ries, V Egea, M Karow, H Kolb, M Jochum, P Neth - Blood, 2007 - ashpublications.org
Human mesenchymal stem cells (hMSCs) represent promising tools in various clinical
applications, including the regeneration of injured tissues by endogenous or transplanted …

Functional roles of matrix metalloproteinases and their inhibitors in melanoma

S Napoli, C Scuderi, G Gattuso, V Di Bella, S Candido… - Cells, 2020 - mdpi.com
The extracellular matrix (ECM) plays an important role in the regulation of the tissue
microenvironment and in the maintenance of cellular homeostasis. Several proteins with a …

The role of chalcones in suppression of NF-κB-mediated inflammation and cancer

VR Yadav, S Prasad, B Sung, BB Aggarwal - International …, 2011 - Elsevier
Although consumption of fruits, vegetables, spices, cereals and pulses has been associated
with lower incidence of cancer and other chronic diseases, how these dietary agents and …

Regulation of matrix metalloproteinase activity in health and disease

E Hadler‐Olsen, B Fadnes, I Sylte… - The FEBS …, 2011 - Wiley Online Library
The activity of matrix metalloproteinases (MMPs) is regulated at several levels, including
enzyme activation, inhibition, complex formation and compartmentalization. Regulation at …

Gelatinase-mediated migration and invasion of cancer cells

M Björklund, E Koivunen - Biochimica et Biophysica Acta (BBA)-Reviews …, 2005 - Elsevier
The matrix metalloproteinases (MMP)-2 and-9, also known as the gelatinases have been
long recognized as major contributors to the proteolytic degradation of extracellular matrix …

Hydrogels and dentin–pulp complex regeneration: from the benchtop to clinical translation

MMS Abbass, AA El-Rashidy, KM Sadek, SE Moshy… - Polymers, 2020 - mdpi.com
Dentin–pulp complex is a term which refers to the dental pulp (DP) surrounded by dentin
along its peripheries. Dentin and dental pulp are highly specialized tissues, which can be …

Multifaceted role of matrix metalloproteinases (MMPs)

D Singh, SK Srivastava, TK Chaudhuri… - Frontiers in molecular …, 2015 - frontiersin.org
Matrix metalloproteinases (MMPs), a large family of calcium-dependent zinc-containing
endopeptidases, are involved in the tissue remodeling and degradation of the extracellular …