Summary Most human Transcription factors (TFs) genes encode multiple protein isoforms
differing in DNA binding domains, effector domains, or other protein regions. The global …

Type-I and-III interferons play a central role in immune rejection of pathogens and tumors,
thus promoting immunogenicity and suppressing tumor recurrence. Double strand RNA is …

Objective Long QT syndrome type 7 (Andersen–Tawil syndrome, ATS), which is caused by
KCNJ2 gene mutation, often leads to ventricular arrhythmia, periodic paralysis and skeletal …

Interferon Regulatory Factor 6 (IRF6) and Grainyhead Like Transcription Factor 3 (GRHL3)
are transcription factors that orchestrate gene regulatory networks required for the balance …

Although genome-wide association studies (GWASs) have identified over 100 colorectal
cancer (CRC) risk loci, an understanding of causal genes or risk variants and their biological …

Defective tissue fusion during mammalian embryogenesis results in congenital anomalies,
such as exencephaly, spina bifida and cleft lip and/or palate. The highly conserved …

Introduction GRHL1 belongs to the family of Grainyhead-like (GRHL). Previous studies have
shown that dysregulation of growth and survival pathways is associated with the GRHL …

Background Transcription factors regulate gene expression by binding to transcription factor
binding sites (TFBSs). Most models for predicting TFBSs are based on position weight …

Abstract Grainyhead-like 2 (Grhl2) is a transcription factor that regulates cell adhesion genes
in mammary ductal development and serves as a repressor of the epithelial–mesenchymal …

The cloaca is a transient structure that forms in the terminal hindgut giving rise to the rectum
dorsally and the urogenital sinus ventrally. Similarly, human hindgut cultures derived from …