[HTML][HTML] Widespread variation in molecular interactions and regulatory properties among transcription factor isoforms

L Lambourne, K Mattioli, C Santoso, G Sheynkman… - bioRxiv, 2024 - ncbi.nlm.nih.gov
Summary Most human Transcription factors (TFs) genes encode multiple protein isoforms
differing in DNA binding domains, effector domains, or other protein regions. The global …

[HTML][HTML] Grainyhead-like-2, an epithelial master programmer, promotes interferon induction and suppresses breast cancer recurrence

I MacFawn, J Farris, P Pifer, NV Margaryan… - Molecular …, 2024 - Elsevier
Type-I and-III interferons play a central role in immune rejection of pathogens and tumors,
thus promoting immunogenicity and suppressing tumor recurrence. Double strand RNA is …

[HTML][HTML] Transcriptome and open chromatin analysis reveals the process of myocardial cell development and key pathogenic target proteins in Long QT syndrome …

P Chen, J Long, T Hua, Z Zheng, Y Xiao… - Journal of Translational …, 2024 - Springer
Objective Long QT syndrome type 7 (Andersen–Tawil syndrome, ATS), which is caused by
KCNJ2 gene mutation, often leads to ventricular arrhythmia, periodic paralysis and skeletal …

[HTML][HTML] Consistent downregulation of the cleft lip/palate-associated genes IRF6 and GRHL3 in carcinomas

L Parisi, C Mockenhaupt, S Rihs, F Mansour… - Frontiers in …, 2022 - frontiersin.org
Interferon Regulatory Factor 6 (IRF6) and Grainyhead Like Transcription Factor 3 (GRHL3)
are transcription factors that orchestrate gene regulatory networks required for the balance …

HSPA12A was identified as a key driver in colorectal cancer GWAS loci 10q26.12 and modulated by an enhancer–promoter interaction

Z Lu, L Fan, F Zhang, C Huang, Y Cai, C Chen… - Archives of …, 2023 - Springer
Although genome-wide association studies (GWASs) have identified over 100 colorectal
cancer (CRC) risk loci, an understanding of causal genes or risk variants and their biological …

[HTML][HTML] Grainyhead-like 2 interacts with noggin to regulate tissue fusion in mouse

ME de Vries, MR Carpinelli, JN Fuller, Y Sutton… - …, 2024 - journals.biologists.com
Defective tissue fusion during mammalian embryogenesis results in congenital anomalies,
such as exencephaly, spina bifida and cleft lip and/or palate. The highly conserved …

Exploration of the Correlation Between GRHL1 Expression and Tumor Microenvironment in Endometrial Cancer and Immunotherapy

S Guo, W Bai, F Cui, X Chen, X Fang… - Pharmacogenomics …, 2024 - Taylor & Francis
Introduction GRHL1 belongs to the family of Grainyhead-like (GRHL). Previous studies have
shown that dysregulation of growth and survival pathways is associated with the GRHL …

[HTML][HTML] Discovery of a non-canonical GRHL1 binding site using deep convolutional and recurrent neural networks

S Proft, J Leiz, U Heinemann, D Seelow… - BMC genomics, 2023 - Springer
Background Transcription factors regulate gene expression by binding to transcription factor
binding sites (TFBSs). Most models for predicting TFBSs are based on position weight …

Expression Patterns of Grainyhead-Like 2 and Ovo-Like 2 in Mouse Mammary Gland Development During Pregnancy, Lactation, and Weaning

M Elfeky, S Matsuoka, I Yamamoto… - Microscopy and …, 2024 - academic.oup.com
Abstract Grainyhead-like 2 (Grhl2) is a transcription factor that regulates cell adhesion genes
in mammary ductal development and serves as a repressor of the epithelial–mesenchymal …

Human Pluripotent Stem Cell Derived Organoids Reveal a Role for WNT Signaling in Dorsal-Ventral Patterning of the Hindgut

N Qu, A Daoud, DO Kechele, JO Munera - bioRxiv, 2024 - biorxiv.org
The cloaca is a transient structure that forms in the terminal hindgut giving rise to the rectum
dorsally and the urogenital sinus ventrally. Similarly, human hindgut cultures derived from …