[HTML][HTML] Widespread variation in molecular interactions and regulatory properties among transcription factor isoforms
L Lambourne, K Mattioli, C Santoso, G Sheynkman… - bioRxiv, 2024 - ncbi.nlm.nih.gov
Summary Most human Transcription factors (TFs) genes encode multiple protein isoforms
differing in DNA binding domains, effector domains, or other protein regions. The global …
differing in DNA binding domains, effector domains, or other protein regions. The global …
[HTML][HTML] Grainyhead-like-2, an epithelial master programmer, promotes interferon induction and suppresses breast cancer recurrence
I MacFawn, J Farris, P Pifer, NV Margaryan… - Molecular …, 2024 - Elsevier
Type-I and-III interferons play a central role in immune rejection of pathogens and tumors,
thus promoting immunogenicity and suppressing tumor recurrence. Double strand RNA is …
thus promoting immunogenicity and suppressing tumor recurrence. Double strand RNA is …
[HTML][HTML] Transcriptome and open chromatin analysis reveals the process of myocardial cell development and key pathogenic target proteins in Long QT syndrome …
P Chen, J Long, T Hua, Z Zheng, Y Xiao… - Journal of Translational …, 2024 - Springer
Objective Long QT syndrome type 7 (Andersen–Tawil syndrome, ATS), which is caused by
KCNJ2 gene mutation, often leads to ventricular arrhythmia, periodic paralysis and skeletal …
KCNJ2 gene mutation, often leads to ventricular arrhythmia, periodic paralysis and skeletal …
[HTML][HTML] Consistent downregulation of the cleft lip/palate-associated genes IRF6 and GRHL3 in carcinomas
L Parisi, C Mockenhaupt, S Rihs, F Mansour… - Frontiers in …, 2022 - frontiersin.org
Interferon Regulatory Factor 6 (IRF6) and Grainyhead Like Transcription Factor 3 (GRHL3)
are transcription factors that orchestrate gene regulatory networks required for the balance …
are transcription factors that orchestrate gene regulatory networks required for the balance …
HSPA12A was identified as a key driver in colorectal cancer GWAS loci 10q26.12 and modulated by an enhancer–promoter interaction
Z Lu, L Fan, F Zhang, C Huang, Y Cai, C Chen… - Archives of …, 2023 - Springer
Although genome-wide association studies (GWASs) have identified over 100 colorectal
cancer (CRC) risk loci, an understanding of causal genes or risk variants and their biological …
cancer (CRC) risk loci, an understanding of causal genes or risk variants and their biological …
[HTML][HTML] Grainyhead-like 2 interacts with noggin to regulate tissue fusion in mouse
ME de Vries, MR Carpinelli, JN Fuller, Y Sutton… - …, 2024 - journals.biologists.com
Defective tissue fusion during mammalian embryogenesis results in congenital anomalies,
such as exencephaly, spina bifida and cleft lip and/or palate. The highly conserved …
such as exencephaly, spina bifida and cleft lip and/or palate. The highly conserved …
Exploration of the Correlation Between GRHL1 Expression and Tumor Microenvironment in Endometrial Cancer and Immunotherapy
S Guo, W Bai, F Cui, X Chen, X Fang… - Pharmacogenomics …, 2024 - Taylor & Francis
Introduction GRHL1 belongs to the family of Grainyhead-like (GRHL). Previous studies have
shown that dysregulation of growth and survival pathways is associated with the GRHL …
shown that dysregulation of growth and survival pathways is associated with the GRHL …
[HTML][HTML] Discovery of a non-canonical GRHL1 binding site using deep convolutional and recurrent neural networks
Background Transcription factors regulate gene expression by binding to transcription factor
binding sites (TFBSs). Most models for predicting TFBSs are based on position weight …
binding sites (TFBSs). Most models for predicting TFBSs are based on position weight …
Expression Patterns of Grainyhead-Like 2 and Ovo-Like 2 in Mouse Mammary Gland Development During Pregnancy, Lactation, and Weaning
M Elfeky, S Matsuoka, I Yamamoto… - Microscopy and …, 2024 - academic.oup.com
Abstract Grainyhead-like 2 (Grhl2) is a transcription factor that regulates cell adhesion genes
in mammary ductal development and serves as a repressor of the epithelial–mesenchymal …
in mammary ductal development and serves as a repressor of the epithelial–mesenchymal …
Human Pluripotent Stem Cell Derived Organoids Reveal a Role for WNT Signaling in Dorsal-Ventral Patterning of the Hindgut
The cloaca is a transient structure that forms in the terminal hindgut giving rise to the rectum
dorsally and the urogenital sinus ventrally. Similarly, human hindgut cultures derived from …
dorsally and the urogenital sinus ventrally. Similarly, human hindgut cultures derived from …