Cancer-associated fibroblasts (CAFs) are a heterogeneous cell population that plays a
crucial role in remodeling the tumor microenvironment (TME). Here, through the integrated …

MacroH2A has established tumour suppressive functions in melanoma and other cancers,
but an unappreciated role in the tumour microenvironment. Using an autochthonous …

The spatial organization of the tumor microenvironment has a profound impact on biology
and therapy response. Here, we perform an integrative single-cell and spatial transcriptomic …

Abstract Purpose of Review Axial spondyloarthritis (AxSpA) is among the rheumatology's
most heritable complex diseases, yet precision medicine at clinics still needs to be explored …

Autologous anti-CD19 chimeric antigen receptor T cell (CAR T) therapy is highly effective in
relapsed/refractory large B cell lymphoma (rrLBCL) but is associated with toxicities that …

Since the advent of single-cell RNA sequencing (scRNA-seq) methodology, single-cell
analysis has become a powerful tool for exploration of cellular networks and dysregulated …

Germinal center (GC) B cells undergo proliferation at very high rates in a hypoxic
microenvironment but the cellular processes driving this are incompletely understood. Here …

The immunological basis of the clinical heterogeneity in autoimmune vasculitis remains
poorly understood. In this study, we conduct single-cell transcriptome analyses on …

The hypothalamus plays a crucial role in the progression of obesity and diabetes; however,
its structural complexity and cellular heterogeneity impede targeted treatments. Here, we …

Introduction Nowadays, it has been recognized that gut microbiome can indirectly modulate
cancer susceptibility or progression. However, whether intratumor microbes are parasitic …