Time-and space-resolved drug delivery is highly demanded for cancer treatment, which,
however, can barely be achieved with a traditional prodrug strategy. In recent years, the …

Cataract is a leading cause of blindness globally, and its surgical treatment poses a
significant burden on global healthcare. Pharmacologic therapies, including antioxidants …

Radiotherapy-induced prodrug activation provides an ideal solution to reduce the systemic
toxicity of chemotherapy in cancer therapy, but the scope of the radiation-activated …

The development of bioorthogonal activation in drug release represents a promising avenue
for precise and safe anti‐cancer treatment. However, two significant limitations currently …

Neuropathic pain is a prevalent form of intermittent chronic pain, affecting approximately 7–
10% of the global population. However, the current clinical administration methods, such as …

A photoredox/copper co‐catalyzed ring‐opening cross‐coupling of aryl azides with
cyclopropanols has been developed with fac‐Ir (ppy) 3 as the photocatalyst. The reaction …

As a novel drug development paradigm, selective activation of prodrugs provides the
potential for precise tumor chemotherapy, thereby presenting an opportunity for advancing …

Chemotherapy is the first-line treatment for cancer, but its systemic toxicity can be severe.
Tumor-selective prodrug activation offers promising opportunities to reduce systemic toxicity …

Bioinspired molecular engineering strategies have emerged as powerful tools that
significantly enhance the development of novel therapeutics, improving efficacy, specificity …

Bioorthogonal click chemistry has played a transformative role in many research fields,
including chemistry, biology, and medicine. Click reactions are crucial to produce …