Diagnosis and management of bipolar disorders
FS Goes - bmj, 2023 - bmj.com
Bipolar disorders (BDs) are recurrent and sometimes chronic disorders of mood that affect
around 2% of the world's population and encompass a spectrum between severe elevated …
around 2% of the world's population and encompass a spectrum between severe elevated …
[HTML][HTML] Molecular mechanisms of schizophrenia: Insights from human genetics
Schizophrenia is a debilitating psychiatric disorder that affects millions of people worldwide;
however, its etiology is poorly understood at the molecular and neurobiological levels. A …
however, its etiology is poorly understood at the molecular and neurobiological levels. A …
Polygenic architecture of rare coding variation across 394,783 exomes
Both common and rare genetic variants influence complex traits and common diseases.
Genome-wide association studies have identified thousands of common-variant …
Genome-wide association studies have identified thousands of common-variant …
Platelet factors are induced by longevity factor klotho and enhance cognition in young and aging mice
Platelet factors regulate wound healing and can signal from the blood to the brain,.
However, whether platelet factors modulate cognition, a highly valued and central …
However, whether platelet factors modulate cognition, a highly valued and central …
New insights from the last decade of research in psychiatric genetics: discoveries, challenges and clinical implications
Psychiatric genetics has made substantial progress in the last decade, providing new
insights into the genetic etiology of psychiatric disorders, and paving the way for precision …
insights into the genetic etiology of psychiatric disorders, and paving the way for precision …
Schizophrenia risk conferred by rare protein-truncating variants is conserved across diverse human populations
D Liu, D Meyer, B Fennessy, C Feng, E Cheng… - Nature …, 2023 - nature.com
Schizophrenia (SCZ) is a chronic mental illness and among the most debilitating conditions
encountered in medical practice. A recent landmark SCZ study of the protein-coding regions …
encountered in medical practice. A recent landmark SCZ study of the protein-coding regions …
[HTML][HTML] Brain-region-specific changes in neurons and glia and dysregulation of dopamine signaling in Grin2a mutant mice
A genetically valid animal model could transform our understanding of schizophrenia (SCZ)
disease mechanisms. Rare heterozygous loss-of-function (LoF) mutations in GRIN2A …
disease mechanisms. Rare heterozygous loss-of-function (LoF) mutations in GRIN2A …
Relating pathogenic loss-of-function mutations in humans to their evolutionary fitness costs
Causal loss-of-function (LOF) variants for Mendelian and severe complex diseases are
enriched in'mutation intolerant'genes. We show how such observations can be interpreted in …
enriched in'mutation intolerant'genes. We show how such observations can be interpreted in …
Deep proteomics identifies shared molecular pathway alterations in synapses of patients with schizophrenia and bipolar disorder and mouse model
Synaptic dysfunction is implicated in the pathophysiology of schizophrenia (SCZ) and
bipolar disorder (BP). We use quantitative mass spectrometry to carry out deep, unbiased …
bipolar disorder (BP). We use quantitative mass spectrometry to carry out deep, unbiased …
[HTML][HTML] Protein interaction studies in human induced neurons indicate convergent biology underlying autism spectrum disorders
Autism spectrum disorders (ASDs) have been linked to genes with enriched expression in
the brain, but it is unclear how these genes converge into cell-type-specific networks. We …
the brain, but it is unclear how these genes converge into cell-type-specific networks. We …