Abstract Dihydroceramide desaturase 1 (DEGS1) converts dihydroceramide (dhCer) to
ceramide (Cer) by inserting a C4-C5 trans (∆ 4E) double bond into the sphingoid backbone …

Dihydroceramides (DhCers) are a type of sphingolipids that for a long time were regarded
as biologically inactive. They are metabolic intermediates of the de novo sphingolipid …

Age-related muscle dysfunction and sarcopenia are major causes of physical incapacitation
in older adults and currently lack viable treatment strategies. Here we find that sphingolipids …

Macroautophagy, usually referred to as autophagy, is a degradative pathway wherein
cytoplasmatic components such as aggregated/misfolded proteins and organelles are …

Sphingolipids are bioactive lipid effectors, which are involved in the regulation of various
cellular signaling pathways. Sphingolipids play essential roles in controlling cell …

The pathogenic relevance of sphingolipid metabolism is increasingly being recognised.
Here we elaborate on a new player within the sphingolipid field: the degs1 enzyme, a …

Sphingosine kinase inhibitor (SKI) II has been reported as a dual inhibitor of sphingosine
kinases (SKs) 1 and 2 and has been extensively used to prove the involvement of SKs and …

Sphingolipid metabolism consists of multiple metabolic pathways that converge upon
ceramide, one of the key molecules among sphingolipids (SLs). In mammals, ceramide …

Dihydrosphingolipids refer to sphingolipids early in the biosynthetic pathway that do not
contain a C4-trans-double bond in the sphingoid backbone: 3-ketosphinganine (3-ketoSph) …

Simple Summary Autophagy is a dynamic and tightly regulated process that seems to have
dual effects in cancer. In some contexts, it can induce carcinogenesis and promote cancer …