The mucus clearance system is the dominant mechanical host defense system of the human
lung. Mucus is cleared from the lung by cilia and airflow, including both two-phase gas-liquid …

Adenosine triphosphate (ATP) has been well established as an important extracellular
ligand of autocrine signaling, intercellular communication, and neurotransmission with …

Abstract Pannexin 1 (PANX1) is an ATP-permeable channel with critical roles in a variety of
physiological functions such as blood pressure regulation, apoptotic cell clearance and …

Pannexins are large-pore forming channels responsible for ATP release under a variety of
physiological and pathological conditions. Although predicted to share similar membrane …

Nucleotides play a crucial role in extracellular signaling across species boundaries. All the
three kingdoms of life (Bacteria, Archea and Eukariota) are responsive to extracellular ATP …

Secretion of pulmonary surfactant in the alveoli of the lungs is essential to maintain lung
function. Stretching of alveoli during lung inflation is the main trigger for surfactant secretion …

The plasma membrane adenosine triphosphate (ATP) release channel pannexin 1 (PANX1)
has been implicated in many physiological and pathophysiological processes associated …

Pannexin 1 (Panx1) is a membrane channel implicated in numerous physiological and
pathophysiological processes via its ability to support release of ATP and other cellular …

Membrane transport is a fundamental means to control basic cellular processes such as
apoptosis, inflammation, and neurodegeneration and is mediated by a number of …

Initial T cell activation is triggered by the formation of highly dynamic, spatiotemporally
restricted Ca2+ microdomains. Purinergic signaling is known to be involved in Ca2+ influx in …