Background: Thiazole is a good pharmacophore nucleus due to its various pharmaceutical
applications. Its derivatives have a wide range of biological activities such as antioxidant …

The incidence of invasive bacterial infections has increased remarkably over the past two
decades, which was mainly attributed to the increasing emergence of drug-resistant bacteria …

Fungal conditions affect a multitude of people worldwide, leading to increased
hospitalization and mortality rates, and the need for novel antifungals is emerging with the …

The increasing incidence of microbial resistance and newly emerging pathogens have
become a serious challenge for public health. More and more efforts have been directed to …

Changes in gene expression cause uncontrolled cell proliferation and consequently tumor
hypoxia. The tumor cells shift their metabolism to anaerobic glycolysis with a significant …

Fungi, which can cause serious infections, results in more than 1.35 million deaths annually
throughout the world. Azole antifungal drugs which could inhibit the enzyme lanosterol 14α …

Abstract New bis-thiazole derivatives (1–10) were synthesized via the ring closure of 1, 1′-
(3, 3′-dimethoxybiphenyl-4, 4′-diyl) bis (thiourea) with phenacyl bromides and evaluated …

Thiazoles and their hydrogenated analogues are not only key structural units in a wide
variety of natural products but they also constitute important building blocks in medicinal …

With the appearance of the antifungal resistance, novel antifungal agents need to be
identified. In this context new 2, 5-disubstituted tetrazole derivatives containing …

ABSTRACT Sixteen new 2-(benzothiazol-2-ylthio)-N′-(3-substituted-4-(3, 4-
substitutedphenyl) thiazol-2 (3H)-ylidene) acetohydrazide derivatives (4a-4p) were …