The rapid emergence of antifungal-resistant human-pathogenic fungi

SR Lockhart, A Chowdhary, JAW Gold - Nature Reviews Microbiology, 2023 - nature.com
During recent decades, the emergence of pathogenic fungi has posed an increasing public
health threat, particularly given the limited number of antifungal drugs available to treat …

Antimicrobial host defence peptides: functions and clinical potential

N Mookherjee, MA Anderson, HP Haagsman… - Nature reviews Drug …, 2020 - nature.com
Cationic host defence peptides (CHDP), also known as antimicrobial peptides, are naturally
occurring peptides that can combat infections through their direct microbicidal properties …

[HTML][HTML] Kaempferol: antimicrobial properties, sources, clinical, and traditional applications

A Periferakis, K Periferakis, IA Badarau… - International journal of …, 2022 - mdpi.com
Flavonoids are a category of plant-derived compounds which exhibit a large number of
health-related effects. One of the most well-known and studied flavonoids is kaempferol …

Antifungal Drug Resistance: Molecular Mechanisms in Candida albicans and Beyond

Y Lee, E Puumala, N Robbins, LE Cowen - Chemical reviews, 2020 - ACS Publications
Fungal infections are a major contributor to infectious disease-related deaths across the
globe. Candida species are among the most common causes of invasive mycotic disease …

[HTML][HTML] Immune defence to invasive fungal infections: A comprehensive review

B Pathakumari, G Liang, W Liu - Biomedicine & Pharmacotherapy, 2020 - Elsevier
The fungal infections are relatively common in humans that can range from common, mild
superficial infections to life-threatening invasive infections. Most of the pathogenic fungi are …

History of the development of antifungal azoles: A review on structures, SAR, and mechanism of action

M Shafiei, L Peyton, M Hashemzadeh, A Foroumadi - Bioorganic chemistry, 2020 - Elsevier
With the increasing risk of invasive and life threating fungal infections, there is now a great
concern regarding the lower discovery rate of antifungal drugs in comparison to …

[HTML][HTML] Antifungal drugs

J Houšť, J Spížek, V Havlíček - Metabolites, 2020 - mdpi.com
We reviewed the licensed antifungal drugs and summarized their mechanisms of action,
pharmacological profiles, and susceptibility to specific fungi. Approved antimycotics inhibit 1 …

[HTML][HTML] Antifungal agents in agriculture: friends and foes of public health

VS Brauer, CP Rezende, AM Pessoni, RG De Paula… - Biomolecules, 2019 - mdpi.com
Fungal diseases have been underestimated worldwide but constitute a substantial threat to
several plant and animal species as well as to public health. The increase in the global …

[HTML][HTML] Using inorganic nanoparticles to fight fungal infections in the antimicrobial resistant era

T Huang, X Li, M Maier, NM O'Brien-Simpson… - Acta Biomaterialia, 2023 - Elsevier
Fungal infections pose a serious threat to human health and livelihoods. The number and
variety of clinically approved antifungal drugs is very limited, and the emergence and rapid …

Cationic chitosan derivatives as potential antifungals: A review of structural optimization and applications

Y Qin, P Li, Z Guo - Carbohydrate polymers, 2020 - Elsevier
The increasing resistance of pathogen fungi poses a global public concern. There are
several limitations in current antifungals, including few available fungicides, severe toxicity …