Since increased cholesterol levels are crucial in determining the development of atheroma,
their reduction represents a mainstay in primary and secondary cardiovascular prevention …

Proprotein convertase subtilisin/kexin type 9 (PCSK-9) inhibitors are a group of drugs whose
main mechanism of action is binding to the PCSK-9 molecule, which reduces the …

Background Lipoprotein (a) concentrations in plasma are associated with cardiovascular
risk in the general population. Whether lipoprotein (a) concentrations or LPA genetic …

Intracerebral haemorrhage (ICH) is associated with the greatest morbidity and mortality of all
stroke subtypes. Established risk factors for ICH include hypertension, alcohol use, current …

Introduction Heart failure (HF) is a heterogeneous clinical syndrome and affects millions of
people all over the world. HF occurs when the cardiac overload and injury, which is a …

Factor VIII (FVIII) is an important component of blood coagulation as its congenital deficiency
results in life-threatening bleeding. Current prophylactic therapy of the disease (hemophilia …

Disturbances in lipid metabolism are among the most important risk factors for
atherosclerotic cardiovascular disease. Proprotein convertase subtilisin/kexin type 9 …

Background—Abdominal aortic aneurysm (AAA) is a common cardiovascular disease
among older people and demonstrates significant heritability. In contrast to similar complex …

There is accumulating evidence that risk profiles differ between coronary artery disease and
abdominal aortic aneurysms (AAAs). However, diabetes mellitus (DM) appears to be …

Background Elevated levels of factor VIII (FVIII) and von Willebrand Factor (vWF) are well-
established risk factors for cardiovascular diseases, in particular venous thrombosis …